Study Comparing Effects of Lower 30 mEqL Versus Higher 35 mEqL Dialysate Bicarbonate in Hospitalized Adults on Maintenance Hemodialysis

What this Trial Is About

Researchers are evaluating the effects of different dialysate bicarbonate levels on heart rhythm abnormalities in adults undergoing maintenance hemodialysis HD who are hospitalized. The study focuses on QTc prolongation and premature ventricular contractions PVCs, which are common in HD patients and linked to sudden cardiac death. The aim is to compare lower versus higher dialysate bicarbonate concentrations to understand their impact on cardiac risks during HD sessions. Participants will be randomly assigned to receive either a lower dialysate bicarbonate concentration of 30 mEqL or a higher concentration of 35 mEqL during their hospital stay. The treatment will be administered during up to six HD sessions or until hospital discharge. Both groups will be monitored closely with telemetry to track heart rhythms and any arrhythmias. Throughout the study, patients will undergo continuous heart monitoring during and between HD sessions to measure QTc duration, PVC burden, clinically significant arrhythmias, intradialytic hypotension, and adverse symptoms. The main outcome is the QTc prolongation observed during the dialysis procedure. The study involves a randomized, double-blind design and will last for the duration of the hospital stay, with assessments focused on cardiac rhythm changes related to dialysate bicarbonate levels.

Trial of Variable Dialysate Bicarbonate