Actively Recruiting
Trial of Variable Dialysate Bicarbonate
Led by Brigham and Women's Hospital · Updated on 2025-11-24
141
Participants Needed
1
Research Sites
162 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death. It is known that higher dialysate bicarbonate is associated with more QTc prolongation during HD sessions. This study aims to assess the effects of lower (30 mEq/L) versus higher (35 mEq/L) dialysate bicarbonate in adult maintenance HD patients admitted to the hospital. The investigators will randomly assign subjects to lower versus higher dialysate bicarbonate concentrations during their hospital stay for up to a maximum of six HD sessions or until their hospital discharge.
CONDITIONS
Official Title
Trial of Variable Dialysate Bicarbonate
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Prevalent end-stage renal disease, on maintenance hemodialysis for more than 90 days
- Age 18 years or older
- Receiving thrice weekly hemodialysis
You will not qualify if you...
- Hemoglobin less than 8.0 g/dL
- Pregnancy
- Any physical, mental, or medical condition limiting the ability to provide written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
K
Katherine S Ravi, MD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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