Actively Recruiting
Triamcinolone With Vitamin D Synergistic Efficacy in Psoriasis
Led by Wright State University · Updated on 2026-02-19
24
Participants Needed
1
Research Sites
371 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
These studies are designed to assess the synergistic efficacy of topical 0.1% triamcinolone cream paired with 40,000 IU of oral vitamin D3 daily in treating mild to moderate psoriasis. The study is designed to have all subjects treated with triamcinolone cream (TAC) for 4 weeks, then will be randomized 1:1 into vitamin D3 or placebo for an additional 12 weeks. At that time, the study will become open-label and all subjects will be placed on (or continue) vitamin D3 for an additional 12 weeks. The study will take place over 28 weeks total.
CONDITIONS
Official Title
Triamcinolone With Vitamin D Synergistic Efficacy in Psoriasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 and older
- Mild to severe plaque psoriasis with 2% or greater Body Surface Area affected
- Psoriasis Area and Severity Score of 2 or greater
- Investigator Grade Assessment showing mild to severe plaque psoriasis
You will not qualify if you...
- Taking medications that alter normal blood ion balance
- Use of calcium supplements (except multivitamins) within 1 month prior to baseline
- Unstable or uncontrolled illnesses including cerebro-cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematologic, neurologic, or psychiatric diseases at screening
- Abnormal lab tests that might affect safety or data integrity
- Use of systemic non-biologic psoriasis therapies within 28 days prior to baseline
- Phototherapy treatments within 28 days prior to baseline
- Use of topical psoriasis treatments within 14 days prior to baseline
- Use of biologic agents within 8 weeks or three half-lives prior to baseline
- History of kidney problems or stones
- History of parathyroid disorders
- Osteoporosis
- History of severe arthritis
- Ongoing use of tanning beds, UV devices, or excessive sunlight exposure
- Unable to understand or complete informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Wright State Physicians
Fairborn, Ohio, United States, 45324
Actively Recruiting
Research Team
M
Manager, Clinical Research Operations
CONTACT
R
Regulatory Specialist
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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