Actively Recruiting
Trifecta-Heart cfDNA-MMDx Study
Led by University of Alberta · Updated on 2026-03-18
300
Participants Needed
12
Research Sites
317 weeks
Total Duration
On this page
Sponsors
U
University of Alberta
Lead Sponsor
N
Natera, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Demonstrate the relationship between DD-cfDNA levels and HLA antibodies in blood transplant recipient and the Molecular Microscope® (MMDx) Diagnostic System results in indication and protocol biopsies from heart transplants.
CONDITIONS
Official Title
Trifecta-Heart cfDNA-MMDx Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All heart transplant recipients undergoing a biopsy for clinical indications or protocol biopsies as determined by their physician or surgeon
- Enrollment based on standard of care biopsies including surveillance biopsies in high-risk patients
- Must provide informed consent to participate in the study
You will not qualify if you...
- Patients who decline participation in the study
- Patients unable to give informed consent
- Recipients of multiple transplanted organs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
Baptist Health Institute for Research and Innovation
Little Rock, Arkansas, United States, 72205
Actively Recruiting
2
Tampa General Hospital, 409 Bayshore Blvd.
Tampa, Florida, United States, 33606
Actively Recruiting
3
Columbia University Medical Center, Columbia Interventional Cardiovascular Care
West New York, New Jersey, United States, 10032
Actively Recruiting
4
Montefiore Medical Center, 3319 Rochambeau Avenue, 2nd FL
The Bronx, New York, United States, 10467
Actively Recruiting
5
Annette C. and Harold C. Simmons Transplant Institute, BaylorScott&White Research Institute
Dallas, Texas, United States, 75246
Actively Recruiting
6
Cardiovascular Medicine, University of Utah Health
Salt Lake City, Utah, United States, 84132
Actively Recruiting
7
Cardiac Transplantation Laboratory, The Victor Chang Cardiac Research Institute
Darlinghurst, Australia, NSW 2010
Not Yet Recruiting
8
Division of Cardiology, University of Alberta
Edmonton, Alberta, Canada, T6G 2R7
Actively Recruiting
9
Institute for Clinical and Experimental Medicine - IKEM Videnska 1958/9
Prague, Czechia, 140 21
Actively Recruiting
10
Heart Failure and Heart Transplant Unit, University of Bologna
Bologna, Italy, 40138
Not Yet Recruiting
11
Silesian Center for Heart Diseases (Ś!ąskie Centrum Chorób Serca w Zabrzu
Zabrze, Poland, 41-800
Actively Recruiting
12
Advanced Heart Failure Transplant Unit
A Coruña, Spain
Not Yet Recruiting
Research Team
K
Konrad Famulski, PhD
CONTACT
R
Robert Polakowski, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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