Study Comparing Early and Standard Ovulation Triggering at Different Follicle Sizes in Modified Natural Cycles for Frozen Embryo Transfer

What this Trial Is About

Researchers are studying the timing of ovulation triggering during frozen embryo transfer FET in assisted reproductive technology ART. The trial compares triggering ovulation at smaller follicle sizes 13-16.9mm with the conventional larger sizes 17-22mm in a modified natural cycle mNC. This study aims to improve scheduling flexibility, optimize treatment protocols, and enhance patient care in fertility clinics. Participants are randomly assigned to one of two groups the control group, where ovulation is triggered at the standard follicle size of at least 17mm, and the experimental group, with triggering at smaller follicle sizes between 13mm and 16.9mm. The study evaluates whether earlier triggering is not worse than the conventional approach in terms of reproductive outcomes. During the study, participants undergo frozen embryo transfer cycles using the assigned ovulation trigger timing. Researchers will measure pregnancy rates up to two weeks after embryo transfer, implantation rates up to eight weeks of gestation, cancellation rates during the procedure, and miscarriage rates up to delivery. The study period extends through these assessments to gather comprehensive data on outcomes and safety.

Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle