Actively Recruiting
Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle
Led by Vida Recoletas Sevilla · Updated on 2026-01-13
572
Participants Needed
1
Research Sites
135 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The rise in frozen embryo transfer (FET) cycles within assisted reproductive technology (ART) has sparked the need to refine endometrial preparation protocols. The switch from hormone replacement cycles (HRT) to natural cycles, poses scheduling challenges onto laboratories, doctors and patients. The modified natural cycle (mNC), offering more precision for scheduling, shows promise but lacks comprehensive data on the potential flexibility of triggering criteria that may allow to control timing in a wider range. This prospective randomized study seeks to address this knowledge gap by evaluating the non-inferiority of triggering ovulation in mNC with follicle diameters of 13-16.9mm compared to the conventional 17-22mm. The study aims to enhance the understanding of the impact of follicle size at ovulation in reproductive outcomes, optimize FET treatments providing a more flexible mNC protocol, and improve patient care in ART clinics.
CONDITIONS
Official Title
Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least one expanded blastocyst (regardless of its quality)
- Spontaneous menstrual cycles
- Consent to undergo frozen embryo transfer in a modified natural cycle
- Female aged 18 to 50 years
You will not qualify if you...
- Abnormal uterine cavity
- Fluid in endometrial cavity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Vida Recoletas Sevilla
Seville, Sevilla, Spain, 41092
Actively Recruiting
Research Team
M
Manuel Fernández Sánchez, MD PhD
CONTACT
C
Clara Palacio de Marco, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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