Actively Recruiting
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Led by Children's Oncology Group · Updated on 2026-05-05
60
Participants Needed
193
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not working well or completely shut down, then it will be difficult or impossible to get pregnant in the future. Triptorelin works by blocking certain hormones and causing the ovaries to slow down or pause normal activity. The triptorelin used in this study stays active in the body for 24 weeks or about 6 months after a dose is given. After triptorelin is cleared from the body, the ovaries resume normal activities. Adding triptorelin before the start of chemotherapy treatment may reduce the chances of damage to the ovaries.
CONDITIONS
Official Title
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is younger than 40 years at enrollment
- Patient is a post-menarchal female with first menstrual period more than 6 months before enrollment
- Newly diagnosed with first cancer, excluding breast cancer (other breast tumor types allowed)
- Planned treatment includes one or more alkylating agents with curative intent (e.g., cyclophosphamide, ifosfamide, procarbazine, chlorambucil, carmustine, lomustine, melphalan, thiotepa, busulfan, nitrogen mustard)
- For patients under 20 years, planned alkylator dose must be at least 4 g/m2 cumulative cyclophosphamide equivalent dose; for patients 20 years or older, any alkylator dose is allowed
- Written informed consent signed by patient or legal guardian
- Meets all institutional, FDA, and NCI requirements for human studies
You will not qualify if you...
- Planned radiation to pelvis or cranial radiation of 30 gray or more to the hypothalamus, including total body irradiation
- Planned bilateral oophorectomy
- Congenital syndromes causing infertility or reduced ovarian reserve (e.g., Turner's Syndrome, Fragile X premutation, Down syndrome)
- Pre-existing seizure disorder, congenital long QT syndrome, pseudotumor cerebri, history of pulmonary embolism, venous thrombosis, or myocardial infarction
- Receipt of long-acting GnRH agonists within 6 months before enrollment (short-acting GnRH agonists for oocyte retrieval and hormonal contraceptives allowed)
- Prior systemic chemotherapy (steroids and intrathecal chemotherapy allowed)
- Prior radiation to pelvis or cranial radiation of 30 gray or more to hypothalamus, including total body irradiation
- Pregnancy
- Lactating females planning to breastfeed during triptorelin therapy
- Sexually active patients of reproductive potential not agreeing to use effective contraception during triptorelin therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 193 locations
1
Children's Hospital of Alabama
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States, 35233
Actively Recruiting
3
USA Health Strada Patient Care Center
Mobile, Alabama, United States, 36604
Actively Recruiting
4
Phoenix Childrens Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
5
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States, 72903
Actively Recruiting
6
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202-3591
Actively Recruiting
7
CARTI Cancer Center
Little Rock, Arkansas, United States, 72205
Actively Recruiting
8
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
9
UC San Diego Moores Cancer Center
La Jolla, California, United States, 92093
Actively Recruiting
10
Loma Linda University Medical Center
Loma Linda, California, United States, 92354
Actively Recruiting
11
Mattel Children's Hospital UCLA
Los Angeles, California, United States, 90095
Actively Recruiting
12
Kaiser Permanente-Oakland
Oakland, California, United States, 94611
Actively Recruiting
13
Children's Hospital of Orange County
Orange, California, United States, 92868
Actively Recruiting
14
Sutter Medical Center Sacramento
Sacramento, California, United States, 95816
Actively Recruiting
15
UC San Diego Medical Center - Hillcrest
San Diego, California, United States, 92103
Suspended
16
Rady Children's Hospital - San Diego
San Diego, California, United States, 92123
Actively Recruiting
17
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
18
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver, Colorado, United States, 80218
Actively Recruiting
19
Connecticut Children's Medical Center
Hartford, Connecticut, United States, 06106
Actively Recruiting
20
Beebe Medical Center
Lewes, Delaware, United States, 19958
Actively Recruiting
21
Beebe South Coastal Health Campus
Millville, Delaware, United States, 19967
Actively Recruiting
22
Helen F Graham Cancer Center
Newark, Delaware, United States, 19713
Actively Recruiting
23
Medical Oncology Hematology Consultants PA
Newark, Delaware, United States, 19713
Actively Recruiting
24
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States, 19718
Actively Recruiting
25
Beebe Health Campus
Rehoboth Beach, Delaware, United States, 19971
Actively Recruiting
26
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, United States, 19801
Actively Recruiting
27
Alfred I duPont Hospital for Children
Wilmington, Delaware, United States, 19803
Actively Recruiting
28
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
29
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, United States, 33908
Actively Recruiting
30
UF Health Cancer Institute - Gainesville
Gainesville, Florida, United States, 32610
Actively Recruiting
31
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, United States, 33021
Actively Recruiting
32
Nemours Children's Clinic-Jacksonville
Jacksonville, Florida, United States, 32207
Actively Recruiting
33
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
34
Nicklaus Children's Hospital
Miami, Florida, United States, 33155
Actively Recruiting
35
Miami Cancer Institute
Miami, Florida, United States, 33176
Actively Recruiting
36
AdventHealth Orlando
Orlando, Florida, United States, 32803
Actively Recruiting
37
Nemours Children's Hospital
Orlando, Florida, United States, 32827
Actively Recruiting
38
Nemours Children's Clinic - Pensacola
Pensacola, Florida, United States, 32504
Actively Recruiting
39
Tampa General Hospital
Tampa, Florida, United States, 33606
Actively Recruiting
40
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, United States, 33607
Active, Not Recruiting
41
Saint Mary's Medical Center
West Palm Beach, Florida, United States, 33407
Actively Recruiting
42
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, United States, 30329
Actively Recruiting
43
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States, 96826
Actively Recruiting
44
OSF Saint Anthony's Health Center
Alton, Illinois, United States, 62002
Actively Recruiting
45
Rush-Copley Medical Center
Aurora, Illinois, United States, 60504
Suspended
46
Saint Mary's Hospital
Centralia, Illinois, United States, 62801
Suspended
47
Lurie Children's Hospital-Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
48
University of Illinois
Chicago, Illinois, United States, 60612
Actively Recruiting
49
Carle at The Riverfront
Danville, Illinois, United States, 61832
Suspended
50
Carle Physician Group-Effingham
Effingham, Illinois, United States, 62401
Suspended
51
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, United States, 61938
Suspended
52
SSM Health Good Samaritan
Mount Vernon, Illinois, United States, 62864
Actively Recruiting
53
Carle BroMenn Medical Center
Normal, Illinois, United States, 61761
Actively Recruiting
54
Carle Cancer Institute Normal
Normal, Illinois, United States, 61761
Actively Recruiting
55
Advocate Children's Hospital-Oak Lawn
Oak Lawn, Illinois, United States, 60453
Actively Recruiting
56
Advocate Children's Hospital-Park Ridge
Park Ridge, Illinois, United States, 60068
Actively Recruiting
57
Memorial Hospital East
Shiloh, Illinois, United States, 62269
Actively Recruiting
58
Saint John's Hospital
Springfield, Illinois, United States, 62702
Actively Recruiting
59
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62702
Actively Recruiting
60
Carle Cancer Center
Urbana, Illinois, United States, 61801
Suspended
61
Rush-Copley Healthcare Center
Yorkville, Illinois, United States, 60560
Suspended
62
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
63
Riley Hospital for Children
Indianapolis, Indiana, United States, 46202
Actively Recruiting
64
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, United States, 50023
Actively Recruiting
65
Saint Anthony Regional Hospital
Carroll, Iowa, United States, 51401
Actively Recruiting
66
Mercy Cancer Center-West Lakes
Clive, Iowa, United States, 50325
Actively Recruiting
67
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, United States, 50325
Actively Recruiting
68
Greater Regional Medical Center
Creston, Iowa, United States, 50801
Actively Recruiting
69
Blank Children's Hospital
Des Moines, Iowa, United States, 50309
Actively Recruiting
70
Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
Actively Recruiting
71
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, United States, 50309
Actively Recruiting
72
Broadlawns Medical Center
Des Moines, Iowa, United States, 50314
Actively Recruiting
73
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States, 50314
Actively Recruiting
74
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, United States, 50314
Actively Recruiting
75
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, Iowa, United States, 50501
Actively Recruiting
76
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, United States, 52242
Actively Recruiting
77
UI Healthcare Mission Cancer and Blood - Pella
Pella, Iowa, United States, 50219
Actively Recruiting
78
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa, United States, 50263
Actively Recruiting
79
Mercy Medical Center-West Lakes
West Des Moines, Iowa, United States, 50266
Actively Recruiting
80
The Iowa Clinic PC
West Des Moines, Iowa, United States, 50266
Actively Recruiting
81
Central Care Cancer Center - Garden City
Garden City, Kansas, United States, 67846
Actively Recruiting
82
Central Care Cancer Center - Great Bend
Great Bend, Kansas, United States, 67530
Actively Recruiting
83
Norton Children's Hospital
Louisville, Kentucky, United States, 40202
Actively Recruiting
84
Children's Hospital New Orleans
New Orleans, Louisiana, United States, 70118
Actively Recruiting
85
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States, 70121
Actively Recruiting
86
Maine Children's Cancer Program
Scarborough, Maine, United States, 04074
Actively Recruiting
87
MaineHealth Maine Medical Center- Scarborough
Scarborough, Maine, United States, 04074
Actively Recruiting
88
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20889-5600
Actively Recruiting
89
Christiana Care - Union Hospital
Elkton, Maryland, United States, 21921
Actively Recruiting
90
C S Mott Children's Hospital
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
91
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States, 48109
Suspended
92
Bronson Battle Creek
Battle Creek, Michigan, United States, 49017
Actively Recruiting
93
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
94
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
95
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
96
Bronson Methodist Hospital
Kalamazoo, Michigan, United States, 49007
Actively Recruiting
97
West Michigan Cancer Center
Kalamazoo, Michigan, United States, 49007
Actively Recruiting
98
Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan, United States, 49009
Actively Recruiting
99
Beacon Kalamazoo
Kalamazoo, Michigan, United States, 49048
Actively Recruiting
100
Trinity Health Muskegon Hospital
Muskegon, Michigan, United States, 49444
Actively Recruiting
101
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan, United States, 49120
Actively Recruiting
102
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan, United States, 49444
Actively Recruiting
103
Corewell Health Reed City Hospital
Reed City, Michigan, United States, 49677
Actively Recruiting
104
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan, United States, 49085
Actively Recruiting
105
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan, United States, 49085
Actively Recruiting
106
Munson Medical Center
Traverse City, Michigan, United States, 49684
Actively Recruiting
107
University of Michigan Health - West
Wyoming, Michigan, United States, 49519
Actively Recruiting
108
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
109
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
110
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
111
Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin, Missouri, United States, 63011
Actively Recruiting
112
Central Care Cancer Center - Bolivar
Bolivar, Missouri, United States, 65613
Actively Recruiting
113
Cox Cancer Center Branson
Branson, Missouri, United States, 65616
Actively Recruiting
114
Mercy Cancer Center - Cape Girardeau
Cape Girardeau, Missouri, United States, 63703
Actively Recruiting
115
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States, 63376
Actively Recruiting
116
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States, 63141
Actively Recruiting
117
Freeman Health System
Joplin, Missouri, United States, 64804
Actively Recruiting
118
Mercy Hospital Joplin
Joplin, Missouri, United States, 64804
Actively Recruiting
119
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, United States, 64108
Actively Recruiting
120
Lake Regional Hospital
Osage Beach, Missouri, United States, 65065
Actively Recruiting
121
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, United States, 65401
Actively Recruiting
122
Phelps Health Delbert Day Cancer Institute
Rolla, Missouri, United States, 65401
Actively Recruiting
123
Heartland Regional Medical Center
Saint Joseph, Missouri, United States, 64506
Actively Recruiting
124
Mercy Hospital Springfield
Springfield, Missouri, United States, 65804
Actively Recruiting
125
CoxHealth South Hospital
Springfield, Missouri, United States, 65807
Actively Recruiting
126
Mercy Infusion Center - Chippewa
St Louis, Missouri, United States, 63109
Actively Recruiting
127
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
128
Mercy Hospital South
St Louis, Missouri, United States, 63128
Actively Recruiting
129
Siteman Cancer Center-South County
St Louis, Missouri, United States, 63129
Actively Recruiting
130
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, United States, 63136
Actively Recruiting
131
Mercy Hospital Saint Louis
St Louis, Missouri, United States, 63141
Actively Recruiting
132
Mercy Hospital Washington
Washington, Missouri, United States, 63090
Actively Recruiting
133
Children's Hospital and Medical Center of Omaha
Omaha, Nebraska, United States, 68114
Actively Recruiting
134
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
135
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
136
Presbyterian Hospital
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
137
University of New Mexico Cancer Center
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
138
Albany Medical Center
Albany, New York, United States, 12208
Actively Recruiting
139
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
Actively Recruiting
140
NYP/Weill Cornell Medical Center
New York, New York, United States, 10065
Actively Recruiting
141
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
142
Stony Brook University Medical Center
Stony Brook, New York, United States, 11794
Actively Recruiting
143
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States, 10467
Actively Recruiting
144
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
145
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
146
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
147
Sanford Broadway Medical Center
Fargo, North Dakota, United States, 58122
Actively Recruiting
148
Children's Hospital Medical Center of Akron
Akron, Ohio, United States, 44308
Actively Recruiting
149
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Actively Recruiting
150
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
151
Dayton Children's Hospital
Dayton, Ohio, United States, 45404
Actively Recruiting
152
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
153
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, United States, 73120
Actively Recruiting
154
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
155
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, United States, 19317
Actively Recruiting
156
Penn State Children's Hospital
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
157
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
158
Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, United States, 19134
Actively Recruiting
159
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
160
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
Actively Recruiting
161
Prisma Health Richland Hospital
Columbia, South Carolina, United States, 29203
Actively Recruiting
162
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, United States, 57117-5134
Actively Recruiting
163
Saint Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
164
The Children's Hospital at TriStar Centennial
Nashville, Tennessee, United States, 37203
Actively Recruiting
165
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
166
Medical City Dallas Hospital
Dallas, Texas, United States, 75230
Actively Recruiting
167
Parkland Memorial Hospital
Dallas, Texas, United States, 75235
Actively Recruiting
168
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States, 75390
Actively Recruiting
169
El Paso Children's Hospital
El Paso, Texas, United States, 79905
Actively Recruiting
170
Cook Children's Medical Center
Fort Worth, Texas, United States, 76104
Actively Recruiting
171
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
172
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
173
Children's Hospital of San Antonio
San Antonio, Texas, United States, 78207
Actively Recruiting
174
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, United States, 23298
Actively Recruiting
175
Carilion Children's
Roanoke, Virginia, United States, 24014
Actively Recruiting
176
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
177
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98109
Actively Recruiting
178
University of Washington Medical Center - Montlake
Seattle, Washington, United States, 98195
Actively Recruiting
179
Providence Sacred Heart Medical Center and Children's Hospital
Spokane, Washington, United States, 99204
Actively Recruiting
180
Madigan Army Medical Center
Tacoma, Washington, United States, 98431
Actively Recruiting
181
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, United States, 54301
Actively Recruiting
182
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, United States, 54303
Actively Recruiting
183
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, United States, 53718
Actively Recruiting
184
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, United States, 53792
Actively Recruiting
185
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
186
Aurora Sinai Medical Center
Milwaukee, Wisconsin, United States, 53233
Actively Recruiting
187
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin, United States, 54154
Actively Recruiting
188
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin, United States, 53081
Actively Recruiting
189
Sheboygan Physicians Group
Sheboygan, Wisconsin, United States, 53081
Actively Recruiting
190
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, United States, 54235-1495
Actively Recruiting
191
CancerCare Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9
Actively Recruiting
192
The Montreal Children's Hospital of the MUHC
Montreal, Quebec, Canada, H3H 1P3
Actively Recruiting
193
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Québec, Canada, G1V 4G2
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here