Actively Recruiting
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Led by Alnylam Pharmaceuticals · Updated on 2026-05-14
1250
Participants Needed
223
Research Sites
386 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to: * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life
CONDITIONS
Official Title
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Documented diagnosis of transthyretin amyloidosis with cardiomyopathy, including hereditary or wild-type forms
- History of heart failure with at least one previous hospitalization or symptoms requiring diuretic treatment
- Screening NT-proBNP level greater than 300 ng/L and less than 8500 ng/L; if atrial fibrillation is present, NT-proBNP must be between 600 ng/L and 8500 ng/L
- May be receiving approved transthyretin stabilizers and background heart failure therapy as determined by the investigator
You will not qualify if you...
- New York Heart Association Class IV heart failure, or Class III heart failure with ATTR amyloidosis disease stage 3
- Polyneuropathy disability Score of IIIa, IIIb, or IV
- Estimated glomerular filtration rate less than 30 mL/min/1.73m2 at screening
- Prior or current treatment with transthyretin-lowering therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 223 locations
1
Clinical Trial Site
La Jolla, California, United States, 92037
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2
Clinical Trial Site
Stanford, California, United States, 94305
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3
Clinical Trial Site
Norwich, Connecticut, United States, 06360
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4
Clinical Trial Site
Washington D.C., District of Columbia, United States, 20010
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5
Clinical Trial Site
Brandon, Florida, United States, 33511
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6
Clinical Trial Site
Miami, Florida, United States, 33125
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7
Clinical Trial Site
Atlanta, Georgia, United States, 30309
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8
Clinical Trial Site
Gainesville, Georgia, United States, 30501
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9
Clinical Trial Site
Tucker, Georgia, United States, 30084
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10
Clinical Trial Site
Evanston, Illinois, United States, 60201
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11
Clinical Trial Site
Indianapolis, Indiana, United States, 46202
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12
Clinical Trial Site
Indianapolis, Indiana, United States, 46260
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13
Clinical Trial Site
Kansas City, Kansas, United States, 66160
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14
Clinical Trial Site
Baltimore, Maryland, United States, 21287
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15
Clinical Trial Site
Boston, Massachusetts, United States, 02115
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16
Clinical Trial Site
Boston, Massachusetts, United States, 02118
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17
Clinical Trial Site
Detroit, Michigan, United States, 48202
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18
Clinical Trial Site
Rochester, Minnesota, United States, 55905
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19
Clinical Trial Site
St Louis, Missouri, United States, 63110
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20
Clinical Trial Site
Manhasset, New York, United States, 11030
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21
Clinical Trial Site
New York, New York, United States, 10029
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22
Clinical Trial Site
New York, New York, United States, 10032
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23
Clinical Trial Site
New York, New York, United States, 10065
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24
Clinical Trial Site
The Bronx, New York, United States, 10467
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25
Clinical Trial Site
Charlotte, North Carolina, United States, 28204
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26
Clinical Trial Site
Cleveland, Ohio, United States, 44195
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27
Clinical Trial Site
Portland, Oregon, United States, 97239
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28
Clinical Trial Site
Lancaster, Pennsylvania, United States, 17602
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29
Clinical Trial Site
Philadelphia, Pennsylvania, United States, 19104
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30
Clinical Trial Site
Charleston, South Carolina, United States, 29425
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31
Clinical Trial Site
Dallas, Texas, United States, 75246
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32
Clinical Trial Site
Houston, Texas, United States, 77030
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33
Clinical Trial Site
Plano, Texas, United States, 75024
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34
Clinical Trial Site
Salt Lake City, Utah, United States, 84132
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35
Clinical Trial Site
Charlottesville, Virginia, United States, 22903
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36
Clinical Trial Site
Falls Church, Virginia, United States, 22042
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37
Clinical Trial Site
Norfolk, Virginia, United States, 23507
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38
Clinical Trial Site
Richmond, Virginia, United States, 23298
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39
Clinical Trial Site
Spokane, Washington, United States, 99204
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40
Clinical Trial Site
Buenos Aires, Argentina, C1025ABI
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41
Clinical Trial Site
Buenos Aires, Argentina, C1093AAS
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42
Clinical Trial Site
Buenos Aires, Argentina, C1199ABB
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43
Clinical Trial Site
Buenos Aires, Argentina, C1428
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44
Clinical Trial Site
Rosario, Argentina, S2000DEJ
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45
Clinical Trial Site
Rosario, Argentina, S2000DSR
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46
Clinical Trial Site
Rosario, Argentina, S2000GAP
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47
Clinical Trial Site
Adelaide, Australia, 5000
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48
Clinical Trial Site
Bedford Park, Australia, 5042
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49
Clinical Trial Site
Box Hill, Australia, 3128
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50
Clinical Trial Site
Chermside, Australia, 4032
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51
Clinical Trial Site
Darlinghurst, Australia, 2010
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52
Clinical Trial Site
Joondalup, Australia, 6027
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53
Clinical Trial Site
Westmead, Australia, 2145
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54
Clinical Trial Site
Braunau am Inn, Austria, 5280
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55
Clinical Trial Site
Graz, Austria, 8036
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56
Clinical Trial Site
Vienna, Austria, 1090
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57
Clinical Trial Site
Vienna, Austria, 1160
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58
Clinical Trial Site
Vienna, Austria, 1210
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59
Clinical Trial Site
Wels, Austria, 4600
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60
Clinical Trial Site
Aalst, Belgium, 9300
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61
Clinical Trial Site
Bruges, Belgium, 8000
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62
Clinical Trial Site
Brussels, Belgium, 1200
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63
Clinical Trial Site
Dendermonde, Belgium, 9200
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64
Clinical Trial Site
Genk, Belgium, 3600
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65
Clinical Trial Site
Ghent, Belgium, 9000
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66
Clinical Trial Site
Hasselt, Belgium, 3500
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67
Clinical Trial Site
Leuven, Belgium, 3000
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68
Clinical Trial Site
Liège, Belgium, 4000
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69
Clinical Trial Site
Roeselare, Belgium, 8800
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70
Clinical Trial Site
Belo Horizonte, Brazil, 30220-140
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71
Clinical Trial Site
Porto Alegre, Brazil, 90035-903
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72
Clinical Trial Site
Porto Alegre, Brazil, 90560-032
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73
Clinical Trial Site
Ribeirão Preto, Brazil, 14026-900
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74
Clinical Trial Site
Ribeirão Preto, Brazil, 14051-140
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75
Clinical Trial Site
Salvador, Brazil, 40170-130
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76
Clinical Trial Site
São Paulo, Brazil, 04038-002
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77
Clinical Trial Site
São Paulo, Brazil, 05403-000
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78
Clinical Trial Site
Calgary, Canada, T2N 4N1
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79
Clinical Trial Site
London, Canada, N6A 5A5
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80
Clinical Trial Site
Santiago, Chile, 7500588
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81
Clinical Trial Site
Santiago, Chile, 8320000
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82
Clinical Trial Site
Dongcheng, China, 100006
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83
Clinical Trial Site
Haidian, China, 100191
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84
Clinical Trial Site
Brno, Czechia, 602 00
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85
Clinical Trial Site
Ostrava, Czechia, 708-52
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86
Clinical Trial Site
Prague, Czechia, 128 21
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87
Clinical Trial Site
Prague, Czechia, 140 21
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88
Clinical Trial Site
Aarhus N, Denmark, 8200
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89
Clinical Trial Site
København Ø, Denmark, 2100
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90
Clinical Trial Site
Odense C, Denmark, 5000
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91
Clinical Trial Site
Chambray-lès-Tours, France, 37170
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92
Clinical Trial Site
Créteil, France, 94000
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93
Clinical Trial Site
Dijon, France, 21000
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94
Clinical Trial Site
La Tronche, France, 38700
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95
Clinical Trial Site
Marseille, France, 13005
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96
Clinical Trial Site
Martinique, France, 97261
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97
Clinical Trial Site
Montpellier, France, 34295
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98
Clinical Trial Site
Paris, France, 75015
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99
Clinical Trial Site
Paris, France, 75018
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100
Clinical Trial Site
Pessac, France, 33600
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101
Clinical Trial Site
Reims, France, 51100
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102
Clinical Trial Site
Rennes, France, 35000
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103
Clinical Trial Site
Rouen, France, 76031
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104
Clinical Trial Site
Saint-Herblain, France, 44093
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105
Clinical Trial Site
Strasbourg, France, 67091
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106
Clinical Trial Site
Toulouse, France, 31059
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107
Clinical Trial Site
Berlin, Germany, 13353
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108
Clinical Trial Site
Cologne, Germany, 50937
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109
Clinical Trial Site
Göttingen, Germany, 37075
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110
Clinical Trial Site
Hanover, Germany, 30625
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111
Clinical Trial Site
Heidelberg, Germany, 69120
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112
Clinical Trial Site
Leipzig, Germany, 04103
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113
Clinical Trial Site
Magdeburg, Germany, 39120
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114
Clinical Trial Site
Munich, Germany, 81377
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115
Clinical Trial Site
Münster, Germany, 48149
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116
Clinical Trial Site
Würzburg, Germany, 97080
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117
Clinical Trial Site
Athens, Greece, 115 27
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118
Clinical Trial Site
Athens, Greece, 115 28
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119
Clinical Trial Site
Heraklion, Greece, 714 09
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120
Clinical Trial Site
Thessaloniki, Greece, 546 36
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121
Clinical Trial Site
Hong Kong, Hong Kong, 999077
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122
Clinical Trial Site
Balatonfüred, Hungary, 8230
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123
Clinical Trial Site
Budapest, Hungary, 1085
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124
Clinical Trial Site
Be’er Ya‘aqov, Israel, 70300
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125
Clinical Trial Site
Haifa, Israel, 3109601
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126
Clinical Trial Site
Jerusalem, Israel, 91120
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127
Clinical Trial Site
Petah Tikva, Israel, 4941492
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128
Clinical Trial Site
Ancona, Italy, 60126
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129
Clinical Trial Site
Bologna, Italy, 40138
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130
Clinical Trial Site
Brescia, Italy, 25123
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131
Clinical Trial Site
Florence, Italy, 50134
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132
Clinical Trial Site
Forlì, Italy, 47121
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133
Clinical Trial Site
Lecce, Italy, 73100
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134
Clinical Trial Site
Milan, Italy, 20122
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135
Clinical Trial Site
Naples, Italy, 80131
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136
Clinical Trial Site
Padova, Italy, 35128
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137
Clinical Trial Site
Pavia, Italy, 27100
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138
Clinical Trial Site
Pisa, Italy, 56124
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139
Clinical Trial Site
Rimini, Italy, 47923
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140
Clinical Trial Site
Roma, Italy, 00168
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141
Clinical Trial Site
Rome, Italy, 00161
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142
Clinical Trial Site
Torino, Italy, 10126
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143
Clinical Trial Site
Bunkyō City, Japan, 113-8655
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144
Clinical Trial Site
Fukuoka, Japan, 810-0001
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145
Clinical Trial Site
Fukuoka, Japan, 812-8582
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146
Clinical Trial Site
Kagawa, Japan, 761-0793
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147
Clinical Trial Site
Kashihara, Japan, 634-8522
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148
Clinical Trial Site
Kobe, Japan, 650-0017
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149
Clinical Trial Site
Kumamoto, Japan, 860-8556
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150
Clinical Trial Site
Kurume, Japan, 830-0011
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151
Clinical Trial Site
Matsumoto-shi, Japan, 390-8621
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152
Clinical Trial Site
Nagoya, Japan, 466-8560
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153
Clinical Trial Site
Nankoku, Japan, 783-0043
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154
Clinical Trial Site
Niigata, Japan, 951-8520
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155
Clinical Trial Site
Okayama, Japan, 700-8558
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156
Clinical Trial Site
Sapporo, Japan, 060-8543
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157
Clinical Trial Site
Sapporo, Japan, 060-8648
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158
Clinical Trial Site
Sendai, Japan, 980-8574
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159
Clinical Trial Site
Suita, Japan, 564-8565
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160
Clinical Trial Site
Tokyo, Japan, 160-8582
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161
Clinical Trial Site
Kajang, Malaysia, 43000
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162
Clinical Trial Site
Kuala Lumpur, Malaysia, 59100
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163
Clinical Trial Site
Eindhoven, Netherlands, 5623 EJ
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164
Clinical Trial Site
Groningen, Netherlands, 9713 GZ
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165
Clinical Trial Site
Maastricht, Netherlands, 6229 HX
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166
Clinical Trial Site
Rotterdam, Netherlands, 3015 GD
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167
Clinical Trial Site
Utrecht, Netherlands, 3584 CX
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168
Clinical Trial Site
Christchurch, New Zealand, 8011
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169
Clinical Trial Site
Hamilton, New Zealand, 3204
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170
Clinical Trial Site
Ålesund, Norway, 6017
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171
Clinical Trial Site
Lørenskog, Norway, 1478
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172
Clinical Trial Site
Carnaxide, Portugal, 2790-134
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173
Clinical Trial Site
Creixomil, Portugal, 4835-044
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174
Clinical Trial Site
Leiria, Portugal, 2410-197
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175
Clinical Trial Site
Lisbon, Portugal, 1169-024
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176
Clinical Trial Site
Lisbon, Portugal, 1649-035
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177
Clinical Trial Site
Vila Real, Portugal, 5000-508
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178
Clinical Trial Site
Viseu, Portugal, 3504-509
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179
Clinical Trial Site
Bucharest, Romania, 022328
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180
Clinical Trial Site
Cluj-Napoca, Romania, 400001
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181
Clinical Trial Site
Košice, Slovakia, 040 11
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182
Clinical Trial Site
Incheon, South Korea, 22332
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183
Clinical Trial Site
Seoul, South Korea, 03080
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184
Clinical Trial Site
Seoul, South Korea, 03722
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185
Clinical Trial Site
Seoul, South Korea, 06351
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186
Clinical Trial Site
Seoul, South Korea, 06591
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187
Clinical Trial Site
A Coruña, Spain, 15006
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188
Clinical Trial Site
Barcelona, Spain, 08035
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189
Clinical Trial Site
Barcelona, Spain, 08036
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190
Clinical Trial Site
Bilbao, Spain, 48013
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191
Clinical Trial Site
El Palmar, Spain, 30120
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192
Clinical Trial Site
Huelva, Spain, 21005
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193
Clinical Trial Site
Jaén, Spain, 23007
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194
Clinical Trial Site
L'Hospitalet de Llobregat, Spain, 8907
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195
Clinical Trial Site
Lleida, Spain, 25198
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196
Clinical Trial Site
Madrid, Spain, 28046
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197
Clinical Trial Site
Madrid, Spain, 28222
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198
Clinical Trial Site
Palma de Mallorca, Spain, 07198
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199
Clinical Trial Site
Pamplona, Spain, 31008
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200
Clinical Trial Site
Salamanca, Spain, 37007
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201
Clinical Trial Site
Santiago de Compostela, Spain, 15706
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202
Clinical Trial Site
Valencia, Spain, 46010
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203
Clinical Trial Site
Valencia, Spain, 46026
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204
Clinical Trial Site
Vigo, Spain, 36213
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205
Clinical Trial Site
Gothenburg, Sweden, 413 45
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206
Clinical Trial Site
Lund, Sweden, 222 42
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207
Clinical Trial Site
Solna, Sweden, 171 76
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208
Clinical Trial Site
Basel, Switzerland, 4051
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209
Clinical Trial Site
Geneva, Switzerland, 1205
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210
Clinical Trial Site
Lucerne, Switzerland, 6000
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211
Clinical Trial Site
Sankt Gallen, Switzerland, 9007
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212
Clinical Trial Site
New Taipei City, Taiwan, 220
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213
Clinical Trial Site
Taichung, Taiwan, 40705
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214
Clinical Trial Site
Taipei, Taiwan, 10002
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215
Clinical Trial Site
Taipei, Taiwan, 112
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216
Clinical Trial Site
Antalya, Turkey (Türkiye), 07070
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217
Clinical Trial Site
Istanbul, Turkey (Türkiye), 34093
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218
Clinical Trial Site
Bellshill, United Kingdom, ML4 3NJ
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219
Clinical Trial Site
Birmingham, United Kingdom, B15 2SQ
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220
Clinical Trial Site
Cardiff, United Kingdom, CF15 9SS
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221
Clinical Trial Site
London, United Kingdom, NW10 2PB
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222
Clinical Trial Site
London, United Kingdom, NW3 2QG
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223
Clinical Trial Site
Manchester, United Kingdom, M15 6SE
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Research Team
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Clinical Trial Information Line
CONTACT
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Clinical Trial Information Line
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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