TriVerity Test for Better Management of Emergency Department Patients With Suspected Infections, Fever, or Fast Heart Rate

What this Trial Is About

Researchers are evaluating the use of the TriVerity™ Acute Infection and Sepsis Test to improve management of emergency department (ED) patients who have suspected infections along with rapid heart rate or fever. This study compares outcomes from a pre-phase where patients received standard care with a post-phase where the TriVerity Test results guide treatment choices. The goal is to see if incorporating this test improves compliance with sepsis treatment guidelines, patient disposition, appropriate use of antibiotics and antivirals, and health economic outcomes. Safety follow-up is included for patients in the post-phase to monitor any effects. During the post-phase, participants will have a 2.5 ml blood sample taken in the ED, processed using the TriVerity Cartridge on the Myrna Instrument. The test provides diagnostic information distinguishing bacterial, viral, or non-infectious inflammation and prognostic data on the need for intensive care. The pre-phase data comes from a retrospective database matched for comparison. Standardized guidance is used to interpret test results and direct clinical management in the post-phase. Participants will be assessed for sepsis treatment compliance within 72 hours of ED admission and monitored through to final disposition orders for up to 35 days. Researchers will track multiple outcomes including appropriate antimicrobial use and patient safety via follow-up calls. Participants need to be reachable by phone for safety checks, and various clinical and laboratory measurements will be collected to evaluate the test's impact on patient care and outcomes.

TriVerity™ for Improved Management of Emergency Department (ED) Patients With Suspected Infections