Actively Recruiting

Age: 18Years +
All Genders
NCT07504731

Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability

Led by Zhongda Hospital · Updated on 2026-04-01

40

Participants Needed

3

Research Sites

58 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This multicenter, physiological, observational study hypothesizes that in moderate to severe ARDS, trunk inclination unloads the chest wall, but its impact on lung mechanics depends on PEEP levels and lung recruitability.

CONDITIONS

Official Title

Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults with moderate to severe ARDS intubated and ventilated according to the Berlin definition (PaO2/FiO2 ratio ≤ 200 mmHg)
  • Under continuous sedation with or without paralysis
Not Eligible

You will not qualify if you...

  • Younger than 18 years old
  • Bronchopleural fistula
  • Pure COPD exacerbation
  • Contraindications to electrical impedance tomography monitoring (e.g., burns, pacemaker, thoracic wounds limiting electrode belt placement)
  • Hemodynamic instability (Systolic BP < 75 mmHg or MAP < 60 mmHg despite vasopressors and/or heart rate < 55 bpm)
  • Contraindications to mobilization (e.g., intracranial hypertension, spinal cord injury)
  • Intra-abdominal hypotension (intra-abdominal pressure ≥ 12 mmHg)
  • Pregnancy
  • Attending physician considers transient high airway pressures unsafe

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 3 locations

1

Zhongda Hospital, Southeast University

Nanjing, Jiangsu, China, 210009

Actively Recruiting

2

The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital

Jinan, Shandong, China, 250014

Actively Recruiting

3

West China Hospital of Sichuan University

Chengdu, Sichuan, China, 610041

Not Yet Recruiting

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Research Team

F

Fengmei Guo, M.D

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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