Actively Recruiting
Tryptophan as a Modulating Factor in the Antimigraine Efficacy of Triptans
Led by University Hospital, Clermont-Ferrand · Updated on 2026-03-09
144
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Clermont-Ferrand
Lead Sponsor
U
University of the Basque Country (UPV/EHU)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Migraine is a leading cause of disability, and while triptans are commonly used to treat migraine attacks, over 20% of patients don't respond well to them. This study aims to understand why some people don't benefit from triptans. One key focus is tryptophan, an amino acid that plays a role in migraine and is involved in producing serotonin, which affects pain and inflammation. The study will compare levels of tryptophan and its by-products in patients who respond well to triptans versus those who don't. It will also look at how conditions like inflammatory bowel disease may affect tryptophan absorption. The goal is to improve migraine treatments tailored to different patient needs, though participants may not experience immediate personal benefits.
CONDITIONS
Official Title
Tryptophan as a Modulating Factor in the Antimigraine Efficacy of Triptans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Cisgender women, premenopausal, aged 18 to 50 years
- Cisgender men, aged 18 to 50 years
- Diagnosed with migraine (according to ICHD-3 criteria)
- Diagnosed as responders or non-responders to triptans (according to the criteria of Sacco et al., 2022)
- Permitted comparison groups include triptans used alone or with other migraine treatments such as NSAIDs, acetaminophen, ergotamine, opioids, or antiemetics
- All routes of administration and dosages of triptans allowed
- Affiliated with a social security system
You will not qualify if you...
- Patients under guardianship, curatorship, deprivation of liberty, or legal protection
- Pregnant and breastfeeding women
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHU de Clermont-Ferrand
Clermont-Ferrand, France
Actively Recruiting
Research Team
L
Lise Laclautre
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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