Actively Recruiting
tSCS + UL Robotics Training in SCI Patients
Led by National University Hospital, Singapore · Updated on 2026-02-25
6
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
Sponsors
N
National University Hospital, Singapore
Lead Sponsor
A
Alexandra Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment upper limb robotic training (ULRT) to improve functional mobility in participants with chronic spinal cord injuries. It also evaluates the impact of the tSCS+ULRT on health-related quality of life (HRQOL), compared to ULRT alone. This is a prospective single-arm crossover study in participants with incomplete chronic traumatic spinal cord injury. 6 to 8 subjects with C2-8 level injuries will be recruited. The intervention includes Phase 1 of training which consists of 16 sessions of ULRT + conventional occupational therapy in 8-10 weeks, and Phase 2 of training which consists of 16 sessions of ULRT training + tSCS + conventional occupational therapy in 8-10 weeks. Outcome measures including mobility function assessment and neuromuscular assessment will be collected at Baseline, Post-Phase 1, Post-Phase 2, and 4 weeks Follow-up. A satisfaction survey on the intervention "ULRT training + tSCS + conventional physiotherapy" will be performed at end of the study.
CONDITIONS
Official Title
tSCS + UL Robotics Training in SCI Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 6 months to 5 years since diagnosis of traumatic spinal cord injury
- Age between 21 and 80 years
- Injury level between C2 and C8 spinal segments
- ISNCSCI Upper Extremity Motor Score greater than 25
- Pinch force greater than 25 Newtons
- Grasp force greater than 100 Newtons
- Able to perform the box and block test
- Able to sit for at least 1 hour without postural hypotension or pressure intolerance
- Able to provide informed consent
- Cleared by neurosurgeon or orthopedic surgeon for transcutaneous spinal cord stimulation
You will not qualify if you...
- Uncontrolled heart or lung disease or cardiac symptoms
- Unstable or significant medical condition interfering with study or outcomes, including uncontrolled neuropathic pain, depression, or severe cognitive impairment
- Unstable or uncontrolled autonomic dysreflexia
- Need for ventilator support
- Spasms limiting ability to participate in training
- Autoimmune cause of spinal cord dysfunction or injury
- History of other neurologic diseases such as stroke, multiple sclerosis, or traumatic brain injury
- Pain in shoulder or hand that limits therapy
- Severe contractures in upper limbs
- Acute upper limb medical conditions like fractures limiting range of motion or weight bearing
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Alexandra Hospital
Singapore, Singapore, Singapore, 159964
Actively Recruiting
Research Team
G
Gobinathan Chandran, MBBS
CONTACT
N
Ning Tang, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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