Actively Recruiting
Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
Led by University of Missouri-Columbia · Updated on 2025-10-08
320
Participants Needed
1
Research Sites
599 weeks
Total Duration
On this page
Sponsors
U
University of Missouri-Columbia
Lead Sponsor
H
Harry S. Truman Memorial Veterans' Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery. Also, early detection of lung cancer with low dose CT screening may cure patients at an early stage. Circulating and disseminated tumor cell (CTC/DTC) and circulating cell-free (cf) DNA isolation from the blood, urine and bone marrow will increase understanding of cancer spread and advance knowledge to develop individualized therapies and improve screening.
CONDITIONS
Official Title
Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects older than 18 years.
- Subjects of all genders and ethnicities.
- Subjects diagnosed with solid cancers of any stage including lung, esophageal, stomach, bile duct/pancreas, colorectal, melanoma, or sarcoma (100 patients).
- Ten patients without cancer history (except basal cell skin cancer) undergoing surgery for benign reasons will serve as controls.
- Cancer diagnosis preferably confirmed by biopsy, but patients with high suspicion by imaging and clinical signs undergoing surgery are included.
- Subjects must be able to give informed consent.
- For lung cancer screening group: aged 55-80 years, with >30 pack years smoking history, and current smoker or quit within last 15 years (100 individuals).
You will not qualify if you...
- Pregnant women.
- Subjects with an active secondary malignancy other than basal cell skin cancer if disease burden is present or if receiving chemotherapy.
- Subjects with hemoglobin less than 8 g/dl on the morning of the procedure.
- Subjects requiring more than 4 units of red packed blood cells transfusion during surgery will not have further blood drawn for analysis.
- Patients with coagulation disorders causing significant bleeding risk preventing bone marrow aspiration.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Harry S Truman Veterans Memorial Hospital
Columbia, Missouri, United States, 65212
Actively Recruiting
Research Team
J
Jussuf T Kaifi, MD
CONTACT
J
Jussuf T Kaifi, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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