Actively Recruiting
Tumor Immune Microenvironment Involvement in Colorectal Cancer Chemoresistance Mechanisms
Led by University Hospital, Grenoble · Updated on 2025-04-20
60
Participants Needed
1
Research Sites
420 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Colorectal cancer is the third most common cancer worldwide and its progression-free survival is still low, around 10 months. Thirthy to 50% of patients do not respond to chemotherapy upon initiation of treatment, suggesting that early development of chemoresistance mechanisms remains a major challenge. In order to better characterize these mechanisms, the aim is to develop a model of tumoroids derived from patients with a colorectal tumors prior to any systemic anti cancer treatment. This project will both allow us to study the role of the immunological microenvironment in chemoresistance and identify new predictive markers of tumor response. It will then serve to develop innovative personalized medicine strategies by targeting the newly identified mechanisms. This study should in fine help to improve the cancer patient's care.
CONDITIONS
Official Title
Tumor Immune Microenvironment Involvement in Colorectal Cancer Chemoresistance Mechanisms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 years or older
- Managed at CHUGA for colorectal adenocarcinoma
- Scheduled for immediate surgical tumor removal
- No prior neo-adjuvant chemotherapy
- Did not object to participation in the CRC-ORGA-2 study
You will not qualify if you...
- Protected by law (pregnant or breastfeeding women, minors, patients under guardianship or trusteeship, persons deprived of liberty, or hospitalized under duress)
- Positive HIV, HBV, or HCV serology
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital of Grenoble Alpes
Grenoble, France, 38043
Actively Recruiting
Research Team
G
GAEL ROTH, MD, PHD
CONTACT
A
ARNAUD MILLET, MD, PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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