Actively Recruiting
Tumor Related Epilepsy
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-05-01
100
Participants Needed
1
Research Sites
857 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. Usually brain tumors are treated by removing as much of the brain tumor as possible without causing problems. Researchers think this may improve the outcome for people with brain tumors. It may completely relieve or greatly reduce the number of seizures they have. Objectives: To evaluate people with brain tumors that are associated with seizures and to offer surgical treatment. Also, to study how surgery affects seizures. Eligibility: People age 8 and older who have a brain tumor with associated seizures. They must be willing to have brain surgery to treat their epilepsy. Design: Participants will be screened with a review of their medical records. Participants will have a medical history and physical exam. Participants will be admitted to the hospital at NIH. They will have Medical history Physical exam Neurological exam Tests of memory, attention, and thinking Questions about their symptoms and quality of life Blood drawn They may also have: MRI or CT scan. They will lie on a table that slides in and out of a machine that takes pictures. For part of the MRI, they will get a dye through an intravenous (IV) catheter. Video electroencephalography monitoring. Electrodes will be placed on the scalp. The participant s brain waves will be recorded while doing normal activities. Participants will be videotaped. Participants will keep a seizure diary before and after surgery. Participants will have surgery to remove their brain tumor and the brain area where their seizures start. They will stay in the hospital up to a week after surgery. Participants have for follow-up visits at NIH.
CONDITIONS
Official Title
Tumor Related Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be 8 years of age or older.
- Have a solitary primary or recurrent brain tumor with associated seizures.
- Tumor may be diagnosed by imaging studies.
- Seizures must have started within three months of tumor diagnosis or be consistent with tumor location.
- Patients with a single previous seizure or controlled seizures after anti-convulsant therapy can participate.
- Willing to have brain surgery to treat epilepsy.
- Able to provide consent or have a parent/guardian to consent if a child.
You will not qualify if you...
- Lack consent capacity due to cognitive impairment making understanding study procedures impossible.
- Patients who are cognitively impaired but still can consent are not excluded.
- Mental disorders alone do not exclude participation.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
G
Gretchen C Scott, R.N.
CONTACT
K
Kareem A Zaghloul, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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