Actively Recruiting
Tumour Characterisation to Guide Experimental Targeted Therapy - National
Led by The Christie NHS Foundation Trust · Updated on 2024-02-07
6000
Participants Needed
20
Research Sites
343 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary aim of TARGET National is to establish a national framework to offer molecular profiling of circulating tumour DNA and/or tumour tissue (optional) to patients with advanced solid cancers referred to any of the Experimental Cancer Medicine Centres (ECMCs) across the UK, in order to help decision making for allocation to molecularly targeted experimental cancer treatments. Patients will be allocated treatment using a national Molecular Tumour Board to find the most suited therapies based on their molecular profiling results. This study aims to recruit up to 6,000 patients with advanced solid tumours across 5 years and proposes to collect blood samples, archival tumour tissue and fresh tissue (optional) The data may also be used for future development of predictive cancer biological markers, the design of clinical trials involving new or existing drugs, discovery of new genetic targets and exploring how resistance to specific anticancer agents arises in patients to help improve future cancer treatment management.
CONDITIONS
Official Title
Tumour Characterisation to Guide Experimental Targeted Therapy - National
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 16 years or over
- Provide written informed consent according to GCP and national regulations
- Confirmed histological or cytological diagnosis of advanced solid cancer
- Referred to any of the ECMCs in the UK
- Considered fit enough to receive an experimental therapeutic agent
- Availability of archival tumour sample if tumour profiling is required
- Willingness to provide blood samples during the study if allocated to matched experimental therapy
You will not qualify if you...
- Known HIV, active Hepatitis B (HBsAg reactive), or active Hepatitis C virus (HCV RNA detected)
- Known current COVID19 positive by PCR or active COVID19 symptoms
- Unable to provide fully informed written consent
- Not eligible for early phase clinical trials as judged by investigator
- Currently receiving systemic anti-cancer therapy unless progressing on hormone-based therapies or tyrosine kinase inhibitors; at least 3 weeks post other systemic therapies required
- Medical, psychological, familial, or sociological conditions that may impair study compliance
- Bleeding diathesis unless anticoagulation can be safely managed for biopsies and blood sampling
- Conditions increasing risk from research biopsies or blood sampling for patient or investigator
AI-Screening
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Trial Site Locations
Total: 20 locations
1
Queen's University Belfast
Belfast, United Kingdom, BT7 1NN
Actively Recruiting
2
University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom, B15 2TH
Actively Recruiting
3
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom, CB20QQ
Actively Recruiting
4
Cardiff University and Velindre Cancer Centre
Cardiff, United Kingdom, CF142TL
Actively Recruiting
5
Western General Hospital Edinburgh Cancer Centre
Edinburgh, United Kingdom, EH2 2SP
Actively Recruiting
6
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom, G12 0YN
Actively Recruiting
7
St.James's University Hospital
Leeds, United Kingdom, LS97TF
Actively Recruiting
8
Leicester Cancer Research Centre
Leicester, United Kingdom, LE27LX
Actively Recruiting
9
Royal Free Hospital
London, United Kingdom, NW3 2QG
Actively Recruiting
10
Kings Health Partners
London, United Kingdom, SE1 9RT
Actively Recruiting
11
Imperial College London
London, United Kingdom, W120NN
Not Yet Recruiting
12
UCL Cancer Institute
London, United Kingdom, WC1E6BT
Actively Recruiting
13
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
14
The Clatterbridge Cancer Centre NHS Foundation Trust
Metropolitan Borough of Wirral, United Kingdom, CH63 4JY
Actively Recruiting
15
The Newcastle Upon Tyne NHS Foundation Trust
Newcastle, United Kingdom, NE7 7DN
Actively Recruiting
16
Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom, OX3 7DQ
Actively Recruiting
17
Royal Preston Hospital
Preston, United Kingdom, PR2 9HT
Actively Recruiting
18
Sheffield University Hospitals NHS Foundation Trust
Sheffield, United Kingdom, S5 7AU
Actively Recruiting
19
University Hospitals Southampton NHS Foundation Trust
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
20
ICR & The Royal Marsden
Sutton, United Kingdom, SM2 5NG
Actively Recruiting
Research Team
M
Matthew Krebs
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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