Actively Recruiting
Turkish Version of the BRIEF-Hammersmith Infant Neurological Examination (HINE) With High-Risk Infants: A Study of Validity and Reliability
Led by Kahramanmaras Sutcu Imam University · Updated on 2025-09-19
120
Participants Needed
1
Research Sites
6 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying high-risk infants who face challenges such as preterm birth, brain injuries, respiratory problems, and other complications that can affect their development. The goal is to create and test a Turkish version of the brief Hammersmith Infant Neurological Examination (BRIEF-HINE), a shorter neurological test designed to identify developmental issues early in these at-risk infants. This observational study focuses on the test's validity and reliability in Turkey. The study will include about 110 high-risk infants who are referred to a Pediatric Rehabilitation Unit for follow-up. Each infant will be assessed using both the full Hammersmith Infant Neurological Examination and the shorter BRIEF-HINE test at 3, 6, and 12 months of age. The shorter test was developed to be quicker and more practical for routine use compared to the full 26-item test. Participants will undergo neurological examinations at these time points, with researchers collecting data through these tests and a sociodemographic form completed at the first visit. The study aims to measure how well the BRIEF-HINE test performs across these intervals to support early identification of developmental problems. The total participation duration for each infant is up to 12 months with ongoing monitoring at specified intervals.
CONDITIONS
Brief Title
Turkish Version of the BRIEF-Hammersmith Infant Neurological Examination (HINE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants aged 3 to 12 months
- Infants with high risk of cerebral palsy due to conditions such as periventricular hemorrhage, intracranial hemorrhage grades 2 to 4, cystic periventricular leukomalacia, stage 3 hypoxic ischemic encephalopathy, neonatal bilirubin encephalopathy, perinatal stroke or asphyxia
- Infants with respiratory distress syndrome, bronchopulmonary dysplasia, or receiving long-term oxygen support
- Infants with sepsis due to gram-negative bacteria, necrotizing enterocolitis, infantile apnea
- Infants with low 5-minute Apgar scores (3 or below), intrauterine growth retardation, multiple births (twins or triplets)
- Preterm infants with retinopathy of prematurity
- Infants with prolonged severe hypoglycemia or hypocalcemia
- Small for gestational age (below 3rd percentile) or large for gestational age (above 97th percentile)
- Infants who received mechanical ventilation for more than 24 hours
- Infants born before 32 weeks gestation and weighing less than 1500 grams
- Infants referred to the Pediatric Rehabilitation Unit for follow-up
You will not qualify if you...
- Infants with any known orthopedic disease
- Infants with any known systemic disease
- Infants with any neurological diagnosis other than cerebral palsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - From 3 to 12 months of age
Participants undergo neurological examinations to assess infant development using the Hammersmith Infant Neurological Examination (HINE) and BRIEF-HINE assessments.
3 visits at 3, 6, and 12 months (in-person)
Trial Site Locations
Total: 1 location
1
Kahramanmaraş Sütçü imam University
Kahramanmaraş, Onikişubat, Turkey (Türkiye), 46100
Actively Recruiting
Research Team
H
Hatice adıgüzel tat, Associate Proffessor
H
hatice Adiguzel tat, Associate Proffessor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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