Actively Recruiting
Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia.
Led by St. Justine's Hospital · Updated on 2025-05-14
1370
Participants Needed
1
Research Sites
520 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study will be to evaluate whether a twice-daily antibiotic regimen is non-inferior to a thrice-daily regimen for the treatment of non-severe community acquired pneumonia in children presenting at a paediatric Emergency Department (ED).
CONDITIONS
Official Title
Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 3 months to 18 years attending the pediatric ED with non-severe pneumonia
- Presence of respiratory symptoms such as cough and/or difficulty breathing
- Signs of pneumonia including fast breathing, abnormal breath sounds, or crackles
- Fever present
- Chest X-ray showing pneumonia as interpreted by the treating physician
You will not qualify if you...
- Signs of severe pneumonia such as severe chest indrawing, shock, severe dehydration, empyema, large pleural effusion, lung abscess, or pneumatocoele
- History of allergic or anaphylactic reaction to penicillin or amoxicillin
- History of serious non-immunoglobulin E-mediated reactions to amoxicillin (e.g., Stevens-Johnson syndrome or toxic epidermal necrolysis)
- Caregiver unable to provide consent due to language barrier or absence
- Unstable chronic illnesses like cystic fibrosis, immune suppression, active tuberculosis, bronchiectasis, or lung cancer
- Persistent or chronic pneumonia lasting more than 2 weeks, suspected atypical pathogens, hospital-acquired pneumonia, aspiration pneumonia, or recurrent pneumonia
- Received amoxicillin within the past month
- Need for hospitalization for other reasons such as persistent vomiting or severe infections requiring intravenous antibiotics
- Previous participation in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU Sainte-Justine
Montreal, Quebec, Canada, H3T1C5
Actively Recruiting
Research Team
J
Jocelyn Gravel, MD
CONTACT
A
Ariane Boutin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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