Actively Recruiting
Two-fraction Proton Therapy With MRI Guidance for Prostate Cancer: A Phase II Trial
Led by Hong Kong Sanatorium & Hospital · Updated on 2026-03-16
35
Participants Needed
1
Research Sites
404 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is testing a shorter treatment method for prostate cancer using proton therapy (PT), which is very precise and may cause fewer side effects compared to traditional radiation. However, it is expensive and not easily accessible for many patients. To make it more affordable and accessible, this study is testing whether 2 fractions of stereotactic body proton therapy (SBPT) can be as safe and effective as the standard 5 sessions.
CONDITIONS
Official Title
Two-fraction Proton Therapy With MRI Guidance for Prostate Cancer: A Phase II Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men under 18 years old with confirmed low- or intermediate-risk prostate cancer according to NCCN guidelines
- Eastern Cooperative Oncology Group (ECOG) performance status less than 2
- Ability to undergo MRI simulation scans without contraindications such as cardiac implantable electronic devices
- Ability to complete the Expanded Prostate Cancer Index Composite (EPIC) questionnaire
You will not qualify if you...
- History of inflammatory bowel disease or cancers other than prostate cancer
- Prior pelvic radiotherapy, chemotherapy, radical prostatectomy, cryosurgery, or focal therapy like high-intensity focused ultrasound (HIFU) for prostate cancer
- History of bladder neck or urethral stricture
- Transurethral resection of the prostate (TURP) within 8 weeks before starting SBPT
- Prostate volume greater than 100 cc on MRI
- Unilateral or bilateral hip replacements
- Nodal or distant metastases shown by CT, MRI, or PSMA PET scans
- Previous androgen deprivation therapy lasting more than 6 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hong Kong Sanatorium and Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
O
Oi Lei Wong, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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