Actively Recruiting
Two Therapeutic Strategies in First-line in Patients With Epithelial Advanced Ovarian Cancer
Led by Groupe Hospitalier Diaconesses Croix Saint-Simon · Updated on 2021-02-11
84
Participants Needed
7
Research Sites
834 weeks
Total Duration
On this page
Sponsors
G
Groupe Hospitalier Diaconesses Croix Saint-Simon
Lead Sponsor
G
GERCOR - Multidisciplinary Oncology Cooperative Group
Collaborating Sponsor
AI-Summary
What this Trial Is About
CHIMOVIP is a study to determine the best therapeutic strategy in patient with ovarian advanced cancer.
CONDITIONS
Official Title
Two Therapeutic Strategies in First-line in Patients With Epithelial Advanced Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed advanced (FIGO stage III or IV) invasive epithelial ovarian cancer, primary peritoneal cancer, or fallopian-tube cancer
- Initial intervention: debulking surgery or diagnostic surgery within 3 weeks before inclusion
- Age 18 to less than 75 years old
- ECOG performance status 2 or less before surgery (ECOG 1 or less and Lee score less than 6 for patients over 70 years old)
- Adequate blood counts within 14 days before inclusion: neutrophils greater than 1500/mm3, platelets greater than 150,000/mm3
- Creatinine clearance MDRD 60 mL/min or higher
- Registered in a national health care system (including CMU)
- Signed and dated informed consent
You will not qualify if you...
- FIGO stage IV extra-abdominal disease except lymph nodes and pleural invasion
- Previous chemotherapy for ovarian cancer
- Left ventricular ejection fraction less than 50% before chemotherapy
- Other invasive cancer within the past 5 years except fully resected basal or squamous cell skin carcinoma
- Use of prophylactic phenytoin or live attenuated viral vaccines such as yellow fever vaccine
- Known hypersensitivity to any study drug components
- Lack of motivation or ability to follow study requirements and constraints
- Pregnancy or breastfeeding
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Centre Georges François Leclerc
Dijon, France
Actively Recruiting
2
Institut Hospitalier Franco-Britannique
Levallois-Perret, France
Actively Recruiting
3
Groupe Hospitalier Diaconesses Croix Saint Simon
Paris, France
Actively Recruiting
4
Hôpital Saint Antoine
Paris, France
Actively Recruiting
5
Hôpital Poissy Saint Germain
Poissy, France
Actively Recruiting
6
CHU Poitiers
Poitiers, France
Actively Recruiting
7
Centre Hospitalier Senlis
Senlis, France
Actively Recruiting
Research Team
R
Richard VILLET, MD
CONTACT
D
Delphine COCHEREAU, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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