Actively Recruiting
Randomized Controlled Clinical Trial Comparing Two-unit Cantilever Implant Prostheses Made of Monolithic Zirconia on Titanium Bases or Porcelain-Fused-to-Metal on Gold Abutments
Led by University of Geneva, Switzerland · Updated on 2022-11-23
38
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Geneva, Switzerland
Lead Sponsor
I
ITI Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to compare two types of two-unit cantilever implant-supported fixed denture prosthetics used to replace missing teeth in the jaw. The study evaluates monolithic zirconia prosthetics bonded to titanium base abutments created through a digital workflow versus porcelain fused-to-metal prosthetics using gold abutments in a conventional workflow. Researchers are assessing differences in survival rates, technical complications, biological outcomes, wear patterns, patient-reported outcomes, and time efficiency. Participants will receive one of two implant-supported cantilever reconstructions. One group will get monolithic zirconia restorations made by CAD/CAM and bonded to titanium bases, with possible ceramic veneering on the visible buccal surface. The other group will receive porcelain fused-to-metal restorations made with a gold abutment using the lost wax technique and conventional impression methods. Both restorations are screw-retained onto implants. The study is randomized and compares outcomes over several years. During the study, participants will be monitored at 1, 3, and 5 years for technical complications, survival rates, biological parameters, wear of the restoration and opposing teeth, and patient-reported outcomes. Additional measures like cost-efficiency, fabrication accuracy, and operator-reported outcomes will be evaluated at baseline. The total study duration includes long-term follow-up to assess both the technical and biological performance of these implant prostheses.
CONDITIONS
Brief Title
Two-unit Cantilever Implant Prostheses Made of Monolithic Zirconia or PFM
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Minimal age of 22 years old
- No general medical condition that contraindicates implant treatment
- Good oral hygiene (Plaque Index 3 20%) and healthy periodontal tissues (Bleeding on Probing 3 20%)
- Two adjacent missing teeth in the posterior upper or lower jaw (first premolar to second molar) with an osseointegrated implant in a correct position for screw-retained prosthesis
- Presence of opposing teeth units
You will not qualify if you...
- Severe bruxism or clenching habits
- Inadequate oral hygiene or persistent mouth infection
- Pregnant or breastfeeding women at inclusion
- Smoking more than 15 cigarettes per day or using chewing tobacco
- Unable or unwilling to cooperate for the trial duration
- Estimated cantilever crown length over 10 mm
- Estimated implant crown height over 15 mm
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single-point intervention at baseline
Participants receive either monolithic zirconia screw retained implant-supported cantilever prostheses on titanium base abutments or porcelain fused-to-metal screw retained implant-supported cantilever prostheses on gold abutments as part of the treatment.
1 visit (in-person)
Duration - Up to 5 years
Participants are monitored for technical complications, survival, biological parameters, wear rate, and patient-reported outcomes over 5 years following the prosthesis placement.
Visits at 1, 3, and 5 years
Trial Site Locations
Total: 1 location
1
University of Geneva
Geneva, Switzerland, 1211
Actively Recruiting
Research Team
J
João Pitta, Dr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here