Actively Recruiting
Two Versus One Week Breast Radiotherapy (RT)
Led by Weill Medical College of Cornell University · Updated on 2025-07-25
400
Participants Needed
3
Research Sites
817 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is comparing two different radiation therapy approaches for early breast cancer to see which one is better for patients. One group will receive radiation over one week (based on the FAST-FORWARD trial), and the other group will receive radiation over two weeks with an extra focused dose (called a "concomitant boost"). The study will look at how the treatments affect side effects, breast appearance, and cancer control in the breast. It also aims to find out if the two-week treatment does a better job at preventing cancer from coming back in the breast over the long term.
CONDITIONS
Official Title
Two Versus One Week Breast Radiotherapy (RT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women status post segmental mastectomy
- For unilateral breast cancer, pT1-2 stage with negative margins
- For bilateral breast cancer, pT1-2 stage with negative margins and/or pTis with negative margins
- Clinically N0 or pathologically pN0-1 or Nx or sentinel node negative
- Ductal carcinoma in situ (DCIS) with negative margins and no DCIS on inked margins
- Women with previously treated contralateral breast cancer can participate
You will not qualify if you...
- Previous radiation therapy to the same (ipsilateral) breast
- More than 90 days since last surgery unless after adjuvant chemotherapy
- More than 60 days since last chemotherapy
- Male breast cancer
- Ongoing treatment for severe autoimmune disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Brooklyn Methodist Hospital
New York, New York, United States, 11215
Actively Recruiting
2
New York Presbyterian Hospital
New York, New York, United States, 11355
Actively Recruiting
3
New York-Presbyterian Weill Cornell Medical College
New York, New York, United States, 11355
Actively Recruiting
Research Team
F
Fabiana Gregucci, MD
CONTACT
F
Fereshteh Talebi, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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