Actively Recruiting
Type 2 Diabetes and Blood Brain Barrier Improvement
Led by University of California, Los Angeles ยท Updated on 2026-03-13
52
Participants Needed
1
Research Sites
138 weeks
Total Duration
On this page
Sponsors
U
University of California, Los Angeles
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to see if a thiamine treatment (taking vitamin B1 capsules) can improve function. Patients will be asked to come to UCLA two times three months apart and each visit will last about 2.5-3 hours.
CONDITIONS
Official Title
Type 2 Diabetes and Blood Brain Barrier Improvement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed type 2 diabetes mellitus (T2DM)
- Outpatient status
- Able to lie flat for imaging procedures
You will not qualify if you...
- History of stroke
- Current thiamine intake
- Known allergy to thiamine
- Seizure disorder
- History of head trauma
- History of myocardial infarction
- Current pregnancy (if female)
- Diagnosed neuropsychiatric disorders such as clinical depression, schizophrenia, or manic-depression
- Diagnosed dementia
- Sleep disordered breathing
- Airway or chest deformities interfering with breathing
- Chronic obstructive pulmonary disease
- Cystic fibrosis
- Presence of brain mass lesions
- History of drug abuse including cocaine, tobacco, or cannabis
- Renal failure requiring dialysis
- Presence of metallic or electronic implants like pacemakers incompatible with 3.0-Tesla MRI scanner
- Non-removable insulin pump or glucose sensor
- Braces
- Body weight over 300 pounds or size incompatible with MRI scanner table
- Any contraindications to MRI such as claustrophobia or metallic-based tattoos
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCLA
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
R
Rajesh Kumar, PhD
CONTACT
D
Dineth R Karunamuni, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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