Actively Recruiting

Early Phase 1
Age: 18Years +
All Genders
Healthy Volunteers
NCT04449198

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Led by Augusta University · Updated on 2025-01-28

24

Participants Needed

1

Research Sites

350 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.

CONDITIONS

Official Title

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Men and premenopausal women
  • All races
  • Clinical diagnosis of insulin-dependent type 1 diabetes (patients only)
Not Eligible

You will not qualify if you...

  • Clinical diagnosis of hepatic, cardiovascular, or renal disease
  • Uncontrolled diabetes (HbA1C >12%)
  • Diabetic complications (i.e. neuropathy)
  • Uncontrolled hypertension (>140/90 mm Hg on therapy)
  • Pregnancy
  • Use of vasoactive medications

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology

Augusta, Georgia, United States, 30912

Actively Recruiting

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Research Team

R

Ryan A Harris, PhD, CEP

CONTACT

J

Jacob Looney, MS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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