Actively Recruiting
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy
Led by University of Alabama at Birmingham · Updated on 2025-12-11
160
Participants Needed
1
Research Sites
416 weeks
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic tau deposition using the PET tracer AV-1451 in participants in the UAB-ADC cohort. The amount and distribution of AV-1451 in the brain will be correlated to demographic, clinical, genetic, and biospecimen data acquired through the separate ongoing UAB-ADC study. Assessment of interactions between race and vascular risk factors, brain tau levels measured with AV-1451-PET, and cognitive status will be the primary outcome of this imaging study. Individuals participating in this AV-1451-PET/MRI study will also be enrolled in an ongoing \[C-11\]PiB-PET/MRI study (IRB-300001005, IND-138128), and their amyloid, tau and cognitive statuses will be compared in terms of race and vascular risk factors.
CONDITIONS
Official Title
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Enrollment in the UAB-ADC study under a separate IRB-approved research protocol
- Enrollment in the UAB-ADC amyloid-PET substudy under a separate IRB-approved research protocol
- Negative urine or serum hCG test within 2 days of [F-18]AV-1451 administration in women of childbearing potential
- Women who are post-menopausal with at least 1 year since last menses or documented surgical sterilization do not require pregnancy testing
You will not qualify if you...
- Meets any exclusion criteria for the UAB-ADC study
- Inability or contraindication for undergoing MRI and/or PET imaging
- Inability to participate in the imaging studies due to severity of dementia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UAB
Birmingham, Alabama, United States, 35233
Actively Recruiting
Research Team
C
Chinara Dosse
CONTACT
C
Carol Chambless
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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