Actively Recruiting
UCAN CAN-DU: Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Disease
Led by The Hospital for Sick Children · Updated on 2024-08-19
4100
Participants Needed
19
Research Sites
448 weeks
Total Duration
On this page
Sponsors
T
The Hospital for Sick Children
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Childhood arthritis is a chronic disabling disease. New medications called biologic therapies are now available to treat arthritis that target key biologic molecules that cause inflammation. Biologic therapies, while very effective in treating arthritis in children, may have serious side effects including infections and potentially cancers, and are very expensive and doctors don't know, which one to choose for which child. The investigators will develop tests that enable them to learn about the biology of each child's arthritis and be able to predict when and which biologic therapy to start and when to stop.
CONDITIONS
Official Title
UCAN CAN-DU: Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or younger
- For Cohort 1: Active arthritis suspected or diagnosed as JIA within 6 months, treatment naive except for NSAIDs
- For Cohort 2: Diagnosed JIA with active arthritis or active systemic JIA, starting or switching biologic therapy
- For Cohort 3: Diagnosed JIA with inactive disease, tapering or stopping biologics
- For Cohort 4: Severe disease with unexplained systemic inflammation, suspected genetic cause, or multiple biologic treatment failures
You will not qualify if you...
- Arthritis explained by another diagnosis (all cohorts)
- Joint injections within 4 weeks before enrollment (Cohort 1)
- Starting biologics only for uveitis without arthritis (Cohort 2)
- Biologic tapering plans longer than 12 months (Cohort 3)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 19 locations
1
Alberta Children's Hospital - University of Calgary
Calgary, Alberta, Canada, T3B 6A8
Actively Recruiting
2
Stollery Children's Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
3
BC Children's Hospital
Vancouver, British Columbia, Canada, V6H 3N1
Actively Recruiting
4
Children's Hospital Health Science Centre Winnipeg
Winnipeg, Manitoba, Canada, R3A 1R9
Actively Recruiting
5
Janeway Children's Hospital and Rehabilitation Centre
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Actively Recruiting
6
IWK Health Centre
Halifax, Nova Scotia, Canada, B3K 6R8
Actively Recruiting
7
McMaster Children's Hospital
Hamilton, Ontario, Canada, L8N 3Z5
Actively Recruiting
8
Children's Hospital, London Health Sciences Centre
London, Ontario, Canada, N6A 5W9
Actively Recruiting
9
Children's Hospital of Eastern Ontario
Ottawa, Ontario, Canada, K1H 8L1
Actively Recruiting
10
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1E8
Actively Recruiting
11
Montréal Children's Hospital
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
12
University of Saskatchewan
Saskatoon, Saskatchewan, Canada, S7N 5A2
Actively Recruiting
13
Amalia Children's Hospital, Radboudumc
Nijmegen, Gelderland, Netherlands, 6525 GA
Actively Recruiting
14
Sint Maartenskinderkliniek
Boxmeer, North Brabant, Netherlands, 6574 NA
Actively Recruiting
15
Emma Children's Hospital, Amsterdam UMC
Amsterdam, North Holland, Netherlands, 1105 AZ
Actively Recruiting
16
Willem-Alexander Children's Hospital, LUMC
Leiden, South Holland, Netherlands, 2333 ZA
Actively Recruiting
17
Sophia Children's Hospital, EMC
Rotterdam, South Holland, Netherlands, 3015 CN
Actively Recruiting
18
Beatrix Children's Hospital, UMCG
Groningen, Netherlands, 9713 GZ
Actively Recruiting
19
Wilhelmina Children's Hospital, UMCU
Utrecht, Netherlands, 3584 EA
Actively Recruiting
Research Team
A
Alexander Mosoiu
CONTACT
A
Amy Xu
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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