Actively Recruiting
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases
Led by Jona Hattangadi-Gluth · Updated on 2024-06-18
60
Participants Needed
1
Research Sites
295 weeks
Total Duration
On this page
Sponsors
J
Jona Hattangadi-Gluth
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in brain metastases patients.
CONDITIONS
Official Title
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older
- One to three brain metastases targets, all smaller than 3 cm in diameter (intact or resected tumor bed)
- Eastern cooperative Oncology Group (ECOG) performance status 0-2 (score of 0, no symptoms; 1, mild symptoms; 2, symptomatic, <50% in bed during the day)
- Ability to answer questions and follow commands via neurocognitive testing
- Estimated life expectancy greater than 6 months
- Pathologic confirmation of extracerebral tumor site (eg, lung, breast, prostate) from either the primary site or a metastatic lesion
- Willingness/Ability to undergo brain MRI scans
- Able to give informed consent
You will not qualify if you...
- Pregnant or nursing women
- Women of childbearing potential unwilling to use adequate contraception
- Inability to complete a magnetic resonance imaging scan with contrast
- Tumor directly invading the critical area to be spared (for example a patient with tumor invading a critical white matter tract; ineligible for cognitive-sparing)
- Planned chemotherapy during SRS (on the day of SRS)
- Previous whole brain radiation therapy
- Leptomeningeal metastases (ineligible for SRS)
- Metastases from primary germ cell tumor, small cell carcinoma, or primary CNS lymphoma (ineligible for SRS)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Moores Cancer Center
San Diego, California, United States, 92037
Actively Recruiting
Research Team
S
Sheila Medina
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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