Actively Recruiting
Uganda Sickle Surveillance Study (US-3)
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2025-06-13
1000000
Participants Needed
4
Research Sites
1007 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital Medical Center, Cincinnati
Lead Sponsor
M
Makerere University
Collaborating Sponsor
AI-Summary
What this Trial Is About
It is estimated that over 250,000 babies are born with sickle cell disease (SCD) annually in sub-Saharan Africa, and only 10% - 50% of them survive beyond five years of age. Data describing the magnitude of the sickle cell problem are lacking in most African countries. The available data on prevalence were mainly from older studies and small numbers of hospitalized patients. In Uganda, approximately 25,000 children are born with SCD but 70-80% die before their 5th birthday. Lehmann and Raper found 'sicklaemia' prevalence of 0.8% and 45% in the Sebei and Bambaa ethnic groups, respectively. A recent study found a SCT and SCD prevalence of 3% - 19% and 0% - 3%, respectively but this study addressed only 5 of Uganda's 111 districts and used a small convenience sample of children aged 6 - 60 months. The objective of this study is to determine the prevalence and map out the burden of SCT and SCD in Uganda.
CONDITIONS
Official Title
Uganda Sickle Surveillance Study (US-3)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Samples may be collected from babies up to 12 months old
- Up to 1,000,000 samples may be collected between 2015 and 2030 based on surveillance findings
You will not qualify if you...
- Repeat samples from the same individuals during the study period will be excluded
AI-Screening
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Trial Site Locations
Total: 4 locations
1
Makerere University
Kampala, Uganda
Actively Recruiting
2
Minister of Health
Kampala, Uganda
Actively Recruiting
3
National Coordinator EID Program
Kampala, Uganda
Actively Recruiting
4
Sickle Cell Clinic Department of Pediatrics & Child Health Mulago Hospital
Kampala, Uganda
Actively Recruiting
Research Team
T
Teresa Latham, MA
CONTACT
W
Wendi Long
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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