Actively Recruiting
UHF ECG in LBBB and Response to CRT Prediction
Led by Faculty Hospital Kralovske Vinohrady · Updated on 2025-07-14
200
Participants Needed
1
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main objective of the project is to demonstrate that in patients with heart failure and QRS complex of nonRBBB morphology lasting over 130 ms, UHF-ECG can differentiate patients with trueLBBB from IVCD better than existing approaches based on the assessment of QRS complex morphology and duration from 12-lead ECG. Another goal of the proposed study is to demonstrate that trueLBBB patients will benefit more from CRT using left bundle branch pacing than from CRT using biventricular pacing. The final aim of the project is to demonstrate that the echocardiographic and clinical response in patients with intraventricular conduction disturbance will be dependent on the degree of reduction in ventricular dyssynchrony after CRT.
CONDITIONS
Official Title
UHF ECG in LBBB and Response to CRT Prediction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Heart failure due to ischemic or non-ischemic cardiomyopathy
- Known coronary angiography performed
- New York Heart Association (NYHA) class II to IV
- Left ventricular ejection fraction (LVEF) 40% or less
- Non-right bundle branch block (non-RBBB) QRS duration over 130 ms (automated measurement)
- Proximal left bundle branch block (LBBB) confirmed by invasive electrophysiology study or non-invasive dyssynchrony assessment if validated during the study
You will not qualify if you...
- Age less than 18 years
- Heart failure caused by reversible conditions
- Moderate to severe aortic valve narrowing (aortic stenosis)
- Pregnancy
- Active inflammation of the heart muscle (myocarditis)
- Hypertrophic cardiomyopathy
- Cardiac valve surgery within the last three months
- Myocardial infarction, percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG) within the last three months
- Severe valve disease requiring intervention
- Severe atherosclerosis of the aorta or femoral arteries
- Life expectancy of one year or less
- Known medical conditions or contraindications that may cause complications during electrophysiology studies
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Faculty Hospital Kralovske Vinohrady
Prague, Česká Republika, Czechia, 10034
Actively Recruiting
Research Team
K
Karol Curila, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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