Early Detection of Ineffective Recanalization After Stroke Using Cerebral Autoregulation Monitoring A Multicenter Study in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy

What this Trial Is About

Researchers are evaluating a monitoring system based on cerebral autoregulation function in patients who have undergone mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion in the anterior circulation. This multicenter, prospective, interventional diagnostic accuracy study aims to explore whether this monitoring can predict poor neurological outcomes shortly after the procedure. The study follows participants for up to 90 days to assess these outcomes. Participants who achieve successful recanalization after mechanical thrombectomy will undergo bedside cerebral autoregulation monitoring immediately after the procedure. This involves continuous near-infrared spectroscopy NIRS to track cerebral oxygen saturation and simultaneous noninvasive or invasive blood pressure measurement for 25-30 minutes. A carotid compression test is also performed to dynamically assess cerebral autoregulation. The cerebral oxygenation index COx is calculated from these measurements to determine the status of autoregulation. During the study, participants will be monitored closely after thrombectomy with cerebral oxygenation and blood pressure recordings, as well as the carotid compression test. Researchers will measure neurological outcomes using scales such as the Modified Rankin Scale up to 90 days after enrollment, and early neurological improvement at around 24 hours. The study includes various assessments and follow-ups to evaluate the predictive value of cerebral autoregulation monitoring for adverse neurological events after stroke treatment.

Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation Monitoring