Actively Recruiting
Ultra Fast-Track vs Fast-Track Protocols in Off-Pump and Minimally Invasive Valve Cardiac Surgery
Led by Azienda Socio Sanitaria Territoriale Ovest Milanese, Ospedale di Legnano · Updated on 2026-04-08
50
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Fast-track cardiac anesthesia (FTCA) has gained significant popularity over the past decades due to its potential to reduce healthcare costs and optimize the use of medical resources. This approach has led anesthesiologists to reconsider the traditional model of cardiac anesthesia, known as Conventional Cardiac Anesthesia (CCA), which historically relied on the administration of high-dose opioids to ensure adequate hemodynamic stability and prolonged postoperative analgesia, thereby reducing the incidence of myocardial ischemia. One of the primary goals of fast-track cardiac anesthesia is early tracheal extubation. Increasing evidence demonstrates that early extubation is associated with a reduction in the length of stay in the intensive care unit (ICU) and overall hospital length of stay, resulting in significant cost savings without negatively affecting patients' clinical outcomes. In contrast, prolonged mechanical ventilation has been shown to have a substantial economic impact and, more importantly, is associated with higher in-hospital mortality and reduced long-term survival, including decreased five-year survival rates. The Ultra Fast Track protocol, which involves extubation directly in the operating room, is currently less commonly used. However, it may further reduce postoperative mechanical ventilation time and the incidence of pulmonary complications, potentially leading to an additional reduction in hospital length of stay. The aim of this study is to compare the Fast Track and Ultra Fast Track protocols in order to evaluate differences in the incidence of respiratory, cardiac, renal, septic, and neurological complications. Postoperative pain will also be assessed using the Numeric Rating Scale (NRS), as well as the incidence of postoperative nausea and vomiting (PONV).
CONDITIONS
Official Title
Ultra Fast-Track vs Fast-Track Protocols in Off-Pump and Minimally Invasive Valve Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years of age
- Scheduled for elective off-pump cardiac surgery or minimally invasive valve surgery via minithoracotomy
- Provide explicit consent and sign the informed consent form
You will not qualify if you...
- Extubation more than 6 hours after surgery
- Positive pregnancy test
- Unable to be awakened in the operating room due to clinical reasons including difficult intubation
- Respiratory failure with P/F ratio less than 200
- Hemodynamic instability requiring more than one vasoactive drug
- Cardiopulmonary bypass lasting more than 150 minutes
- Active bleeding during surgery
- Core body temperature below 356C
AI-Screening
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Trial Site Locations
Total: 1 location
1
Trial Office
Legnano, Italy, Italy, 20025
Actively Recruiting
Research Team
T
Trial office Trial Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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