Actively Recruiting
Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer
Led by City of Hope Medical Center · Updated on 2025-10-29
82
Participants Needed
7
Research Sites
126 weeks
Total Duration
On this page
Sponsors
C
City of Hope Medical Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial tests how well ultra-hypofractionated (UF) whole breast irradiation (WBI) with lumpectomy cavity boost (CB) works in treating patients with stage I-III breast cancer. Breast conservation therapy (BCT) is the recommended treatment for patients with early stage breast cancer. BCT involves a lumpectomy followed by breast radiation. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Traditionally, WBI has been given once daily over 5-6 weeks and then those at high-risk for recurrence receive additional radiation (boost) to the lumpectomy cavity daily over 4-8 days. This has now been replaced by moderate hypofractionated radiation. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Although moderate hypofractionated radiation therapy reduces the length of treatment from 6-7 weeks to 3-4 weeks, the length of treatment still remains a barrier for many patients. UF-WBI with CB delivers radiation to the whole breast and the surgical cavity at the same time over 5 daily treatments. Giving UF-WBI with CB may prevent recurrence and prolong survival as well as improve the quality of life in patients with stage I-III breast cancer.
CONDITIONS
Official Title
Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide documented informed consent
- Female aged 40 years or older
- Able to read and understand English for questionnaires
- Histologically confirmed epithelial breast cancer
- Have undergone breast conserving surgery with negative margins (re-excision allowed)
- Have had surgical staging of the axilla (sentinel lymph node biopsy or axillary lymph node dissection)
- Have at least one high-risk feature requiring lumpectomy cavity boost
- Physician-reported "Excellent" or "Good" breast cosmesis post-lumpectomy and before radiation
- Women of childbearing potential must have a negative urine or serum pregnancy test
You will not qualify if you...
- Prior radiation to the involved breast region that would prevent further irradiation
- Regional lymph nodes requiring comprehensive nodal radiation including supraclavicular fossa involvement
- Clinically significant uncontrolled illness
- Stage IV breast cancer
- Diagnosis of Paget's disease of the nipple
- Other prior or active malignancy interfering with study safety or efficacy
- Pregnant or breastfeeding
- Inability to comply with study procedures or logistics as judged by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
City of Hope at Arcadia
Arcadia, California, United States, 91007
Actively Recruiting
2
City of Hope Medical Center
Duarte, California, United States, 91010
Actively Recruiting
3
City of Hope at Irvine Lennar
Irvine, California, United States, 92618
Not Yet Recruiting
4
City of Hope Antelope Valley
Lancaster, California, United States, 93534
Actively Recruiting
5
City of Hope South Pasadena
South Pasadena, California, United States, 91030
Actively Recruiting
6
City of Hope at South Bay
Torrance, California, United States, 90503
Actively Recruiting
7
City of Hope Upland
Upland, California, United States, 91786
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here