Actively Recruiting
Ultradian Steroid Rhythms in Adrenal Incidentalomas
Led by University Hospital, Bordeaux · Updated on 2026-04-23
40
Participants Needed
1
Research Sites
76 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Twenty to 40% of adrenal incidentalomas are responsible for MACS (mild autonomous cortisol producing secretion). The biological tools used in current practice to explore MACS do not provide precise information on cortisol production abnormalities. This study is a comparative analysis of the dynamics/rhythmicity of interstitial cortisol and other steroid concentrations between MACS and non-secreting adenomas (ANS). Using the original and innovative U-RHYTHM system, interstitial fluid samples will be taken every 20 minutes for 24 to 48 hours from patients with MACS or non-secreting adenomas, and steroid assays will be performed in the perfusates to analyze steroid hormone production over 24 hours.
CONDITIONS
Official Title
Ultradian Steroid Rhythms in Adrenal Incidentalomas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 85 years
- One or more adrenal nodules with cortical appearance on CT scan
- Affiliated with or beneficiary of a social security scheme
- For MACS group: serum cortisol after dexamethasone test > 50 nmol/L (1.8 g/dL) with valid dexamethasone level
- For MACS group: morning plasma ACTH concentration 2.5 pmol/L (11 pg/mL) or less
- For non-secreting adenoma group: plasma cortisol after dexamethasone test 50 nmol/L (1.8 g/dL) or less
You will not qualify if you...
- Age under 18 years
- Pregnant or breastfeeding
- Use of oral estrogens within 6 weeks prior to sampling
- Known adrenal insufficiency or treatment with steroids or other interfering drugs
- Participation in another study
- Under legal protection or deprived of liberty
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hôpital Haut-Levêque
Pessac, France, 33600
Actively Recruiting
Research Team
A
Amandine FERRIERE, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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