Actively Recruiting
Ultrafiltration Versus IV Diuretics in Worsening Heart Failure
Led by Nuwellis, Inc. · Updated on 2025-05-15
372
Participants Needed
17
Research Sites
235 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The REVERSE-HF study is a randomized controlled trial to evaluate clinical outcomes of adjustable ultrafiltration with the Aquadex System as compared to adjustable IV loop diuretics in patients with worsening heart failure (HF) and fluid overload.
CONDITIONS
Official Title
Ultrafiltration Versus IV Diuretics in Worsening Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- Man, or non-pregnant woman
- Admitted to the hospital with a diagnosis of acute decompensated heart failure
- On regularly prescribed oral loop diuretics, Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors or a Mineralcorticoid Receptor Antagonists (MRA) prior to admission
- Fluid overload manifested by at least three clinical indications (e.g., edema, an excess of at least 10 pounds of fluid, etc.)
- Provide written informed consent
You will not qualify if you...
- New diagnosis of heart failure
- Acute coronary syndromes
- Creatinine 64 3.0 mg/dl or planned renal replacement therapies at the time of enrollment
- Contraindications to systemic anticoagulation
- Severe concomitant disease expected to prolong hospitalization or cause death in less than 90 days
- Sepsis or ongoing systemic infection
- Active myocarditis
- Constrictive pericarditis or restrictive cardiomyopathy
- Severe aortic stenosis
- Any condition in the opinion of the investigator that would prevent the patient from follow-up/survival
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
Banner Health
Tucson, Arizona, United States, 85721
Actively Recruiting
2
MemorialCare, Long Beach Medical Center
Long Beach, California, United States, 90806
Actively Recruiting
3
Sharp Memorial Hospital, San Diego Cardiac Center
San Diego, California, United States, 92123
Actively Recruiting
4
University of California San Francisco
San Francisco, California, United States, 94143
Withdrawn
5
BayCare Medical Group, Morton Plant
Clearwater, Florida, United States, 33756
Completed
6
St. Joseph's Hospital
Tampa, Florida, United States, 33614
Withdrawn
7
University of Kentucky
Lexington, Kentucky, United States, 40536
Actively Recruiting
8
Henry Ford Health
Detroit, Michigan, United States, 48202
Actively Recruiting
9
Mount Sinai Morningside
New York, New York, United States, 10025
Actively Recruiting
10
The Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
11
Northwell Health
New York, New York, United States, 10075
Actively Recruiting
12
The Christ Hospital
Cincinnati, Ohio, United States, 45219
Actively Recruiting
13
The Ohio State University
Columbus, Ohio, United States, 43215
Actively Recruiting
14
Abington Jefferson Health
Abington, Pennsylvania, United States, 19001
Actively Recruiting
15
Jackson Madison County General Hospital
Jackson, Tennessee, United States, 38301
Actively Recruiting
16
Baylor Scott & White Research Institute
Dallas, Texas, United States, 75207
Actively Recruiting
17
Sentara Norfolk General Heart Hospital
Norfolk, Virginia, United States, 23507
Actively Recruiting
Research Team
M
Megan Cotts
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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