Actively Recruiting
Ultralow Dose PET Imaging for 18F-NaF Uptake
Led by Akiva Mintz · Updated on 2025-12-16
200
Participants Needed
2
Research Sites
251 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate an investigational ultralow dose positron emission tomography (PET imaging) technique for increased bone turnover that is found in diseases such as cancer, trauma, infection, arthritis, and other benign diseases of bone detection and monitoring. The main question it aims to answer is: Can the investigators optimize the timing, scan duration, and image reconstruction to reduce the radiation dose 10-100 fold of the current clinical standard? Participants will be injected with a radioactive tracer called Fluorine-18 (18F)-sodium fluoride (NaF) and be imaged on a new type of high sensitivity PET scanner for up to 3 hours.
CONDITIONS
Official Title
Ultralow Dose PET Imaging for 18F-NaF Uptake
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 18 years
- Ability to provide informed consent and comply with study procedures
- For female participants: Must not be pregnant or breastfeeding; negative pregnancy test required for women of childbearing potential
You will not qualify if you...
- Participants exceeding 50 millisievert total annual radiation exposure from prior research scans, including this study
- More than four prior enrollments in this study
- Severe claustrophobia, chronic pain, or musculoskeletal conditions preventing completion of the PET scan
- Concurrent treatments interfering with radiotracer uptake as determined by the Principal Investigator
- Pregnant or breastfeeding individuals (negative pregnancy test required)
- Inability to provide informed consent
- Any condition that may compromise participant safety or study integrity as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Nuclear Imaging Institute
Englewood, New Jersey, United States, 07631
Actively Recruiting
2
Nuclear Imaging Institute
Englewood, New Jersey, United States, 07631
Enrolling by Invitation
Research Team
B
Barbara Blanchfield
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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