Actively Recruiting
Ultrasound-assisted, Catheter-directed Thrombolysis for Acute Intermediate-high-risk Pulmonary Embolism
Led by Niguarda Hospital · Updated on 2026-04-16
180
Participants Needed
1
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this retrospective and prospective multicenter study is to evaluate the incidence of pulmonary hypertension (PH) within 6 months from ultrasound-assisted, Catheter-directed Thrombolysis for acute intermediate- high-risk Pulmonary Embolism
CONDITIONS
Official Title
Ultrasound-assisted, Catheter-directed Thrombolysis for Acute Intermediate-high-risk Pulmonary Embolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients admitted with acute intermediate-high risk pulmonary embolism as defined by ESC guidelines
- Symptoms started within the previous 14 days, with or without deep venous thrombosis
- Pulmonary embolism confirmed by contrast-enhanced chest CT with embolus in a main or proximal lower lobe pulmonary artery
- Echocardiographic evidence of right ventricular dysfunction
- Patients with high-risk pulmonary embolism or worsening hemodynamics on anticoagulation who have absolute contraindications to systemic thrombolysis and symptoms started within 14 days
- Patients with surgery-related embolic complications within 48 hours
You will not qualify if you...
- Younger than 18 years old
- Unable to provide informed consent
- Pregnant
- Received fibrinolytic drugs within the previous 4 days
- Bleeding disorders or known bleeding risk
- Low platelet count (less than 100,000/uL)
- Gastrointestinal bleeding within the last 3 months
- Presence of malignant cancer with survival less than 6 months
- Advanced chronic kidney disease (eGFR less than 30 ml/min or on dialysis)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
ASST GOM Niguarda
Milan, Italia, Italy, 20162
Actively Recruiting
Research Team
A
Alice Sacco, MD
CONTACT
D
Dario Brunelli, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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