Actively Recruiting
Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials
Led by Centre Hospitalier Régional d'Orléans · Updated on 2025-05-15
24
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E/E') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure. The main objective is to find out which spontaneous breathing trial is the least demanding in terms of heart work. Investigators will compare 3 consecutive spontaneous breathing trials in a random order to see if one is superior to the others. Participants will not have to perform any specific procedure apart from breathing without respiratory support during the spontaneous breathing trial. During these trials, the investigator will perform cardiac ultrasound measurements.
CONDITIONS
Official Title
Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Intubated patient undergoing invasive mechanical ventilation for at least 24 hours and scheduled for a spontaneous breathing trial
- Richmond Agitation Sedation Scale (RASS) between -1 and +1
- Patient at high risk of re-intubation with at least one of the following: underlying cardiac disease (left ventricular dysfunction with ejection fraction ≤ 45%, ischemic heart disease, chronic atrial fibrillation, history of cardiogenic pulmonary edema) or underlying respiratory disease (COPD, emphysema, bronchial dilatation, asthma, obesity/hypoventilation syndrome, restrictive lung disease)
You will not qualify if you...
- Neuromuscular pathology (myasthenia type) before hospitalization
- Pregnant or breast-feeding women
- Patient already included in the study
- Protected person (under guardianship or curatorship)
- Person under court protection
- Person not affiliated to a social security scheme
AI-Screening
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Trial Site Locations
Total: 1 location
1
Chu Orleans
Orléans, France, 45067
Actively Recruiting
Research Team
G
Guillaume Fossat, Pt, Msc, PhD student
CONTACT
E
Elodie Pougoue
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
6
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