Actively Recruiting
Ultrasound-guided Cryobiopsy of Mediastinal/Hilar Lymph Nodes
Led by University of Zurich · Updated on 2025-04-10
136
Participants Needed
1
Research Sites
251 weeks
Total Duration
On this page
Sponsors
U
University of Zurich
Lead Sponsor
A
Aarau Cantonal Hospital (KSA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
EBUS-guided cryobiopsy of mediastinal and hilar lymph nodes has shown to be a useful diagnostic tool to obtain tissue for histological analysis and further targeted therapies in lung malignancies. Due to the large size and better quality of the tissue samples, a higher diagnostic yield than with transbronchial needle aspiration (TBNA) can be expected, especially in non-solid tumors. In previous studies different biopsy protocols were used. The freezing time of cryoprobe (which defines the sample sizes) ranged from 3 to 7 s and the number of biopsies was between 1 and 4 samples. It is therefore unclear what freezing times and biopsy frequency are required to obtain the best histological information.
CONDITIONS
Official Title
Ultrasound-guided Cryobiopsy of Mediastinal/Hilar Lymph Nodes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least one mediastinal lesion or hilar lymph node 1 cm or longer in the short axis requiring diagnostic bronchoscopy
- Age between 18 and 90 years
- Written informed consent after participant's information
You will not qualify if you...
- Age less than 18 or greater than 90 years
- Unable to provide informed consent (including impaired judgment or communication barriers)
- Contraindication against bronchoscopy (e.g., co-morbidities)
- Mediastinal abscess or cyst
- Abnormal blood supply to the lesion seen by EBUS bronchoscope
- INR greater than 1.5 or platelet count less than 100 G/l
- Use of clopidogrel or other new antiplatelet drugs within 7 days before biopsy (salicylic acid alone allowed)
- Use of anticoagulation with NOAC within 48 hours before biopsy
- Presence of pulmonary lesions suspicious for lung carcinoma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Jürgen Hetzel
Basel, Switzerland
Actively Recruiting
Research Team
C
Carolin Steinack
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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