Comparing Ultrasound-Guided Dextrose Injection to Dextrose Plus Methylprednisolone for Treating Carpal Tunnel Syndrome in Adults

What this Trial Is About

Researchers are comparing two ultrasound-guided injection treatments for patients with carpal tunnel syndrome CTS. The trial evaluates whether injecting 4 ml of 5% dextrose alone or 3 ml of 5% dextrose combined with 1 ml of 40 mgml methylprednisolone differs in effectiveness. The study aims to assess pain relief, symptom severity, functional status, grip strength, median nerve size, and quality of life over six months after treatment. Participants are randomly assigned to receive either a single ultrasound-guided injection of 4 ml 5% dextrose or a single injection of 3 ml 5% dextrose plus 1 ml 40 mgml methylprednisolone acetate in the carpal tunnel. Both patients and evaluators are blinded to the treatment allocation. The study includes adults aged 18 to 80 with idiopathic CTS, and one hand per participant is treated based on the worst symptoms. Participants will undergo evaluations before injection and at 4, 12, and 24 weeks afterward. Assessments include pain intensity using a visual scale, symptom severity and function via questionnaire, grip strength measurement, ultrasound imaging of the median nerve, and quality of life surveys. Allowed pain medications will exclude acetaminophen and tramadol for two days before evaluations. The study excludes other physical therapies or invasive procedures during the trial period.

Ultrasound-guided Dextrose Injection Versus Dextrose With Methylprednisolone in Carpal Tunnel Syndrome