Actively Recruiting
Ultrasound and Respiratory Physiological Signals in Lung Diseases
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-09-02
25
Participants Needed
1
Research Sites
157 weeks
Total Duration
On this page
Sponsors
F
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lead Sponsor
O
Onera BV
Collaborating Sponsor
AI-Summary
What this Trial Is About
The use of lung ultrasound is instrumental in the evaluation of many chest pathologies and its ability to detect pleuro-pulmonary pathology is widely accepted. However, the use of ultrasound to explore the state of the peripheral lung parenchyma, when the organ is still aerated, is a relatively new application. Horizontal and vertical artifacts are separate and distinct artifacts that can be seen during ultrasound examination of the lungs. While the practical role of lung ultrasound artifacts is accepted to detect and monitor many conditions, further research is needed for the physical interpretation of ultrasound artifacts. These artifacts are diagnostic signs, but we don't fully understand their origin. The artifactual information deriving from the surface acoustic interaction, beyond the pleural line, in the ultrasound images of the normally aerated and non-deflated lung, represents the final result of complex interactions of acoustic waves with a specific three-dimensional structure of the biological tissue. Thus, the umbrella term "vertical artifacts" oversimplifies many physical phenomena associated with a pathological pleural plane. There is growing evidence that vertical artifacts are caused by physiological and pathological changes in the superficial lung parenchyma. Therefore, the need emerges to explore the physical phenomena underlying the artifactual ultrasound information deriving from the surface acoustic interaction of ultrasound with the pleuro-pulmonary structures.
CONDITIONS
Official Title
Ultrasound and Respiratory Physiological Signals in Lung Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- inpatients admitted to the hospital due to diffuse interstitial lung diseases during exacerbation OR infectious interstitial pneumonia not caused by SARS-CoV-2 OR acute exacerbation of chronic obstructive pulmonary disease.
- Outpatients with pulmonary paraseptal and/or panlobular emphysema and/or chronic obstructive pulmonary disease during stable phase.
- Patients able to give written informed consent.
You will not qualify if you...
- history of skin irritation, redness, itching or allergic cutaneous symptoms.
- Allergic reactions to adhesives or hydrogels.
- Family history of adhesive skin allergies.
- Presence of severe skin conditions such as wounds, burns or on any damaged skin.
- Presence of strong magnetic fields in the study setting.
- Presence of electromagnetic disturbances or significant ionizing radiation sources which might lead to signal artifacts.
- Use of external cardiac defibrillators.
- Use of diaphragmatic pacers.
- Use of extra cardiac stimulators.
- Pregnancy.
- Pediatric population.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Italy, 00168
Actively Recruiting
Research Team
R
Riccardo Inchingolo, MD, PhD
CONTACT
A
Andrea Smargiassi, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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