Synergistic Assessment of Ultrasound Data and Respiratory Physiological Signals in Lung Diseases

What this Trial Is About

This research investigates the use of lung ultrasound and respiratory physiological signals to better understand lung diseases such as interstitial lung diseases during exacerbations, infectious interstitial pneumonia, and chronic obstructive pulmonary disease (COPD) in various stages. The study focuses on exploring the physical origins and diagnostic value of ultrasound artifacts, especially vertical artifacts that arise from complex interactions of ultrasound waves with lung tissue, which are not yet fully understood. By examining these artifacts, researchers aim to improve knowledge about the superficial lung parenchyma's physiological and pathological changes. Participants will undergo thoracic ultrasonographic scans using clinical machines and research platforms, with metal skin markers placed to align ultrasound images with computed tomography (CT) scans for precise comparison. On the same day as enrollment, a wearable system with sensors applied to the upper chest will collect physiological data including electrocardiography (ECG), respiratory effort and flow, physical activity, body position, and sound pressure levels. This combined approach aims to correlate ultrasound data with tomographic and cardio-respiratory signals from a diverse patient group. During the study, researchers will evaluate lung involvement using ultrasound, assess emphysema types and interstitial lung disease features through CT scans, all at enrollment. Data collection includes ultrasound videos, CT images, and continuous physiological monitoring from the wearable sensors. The study involves both inpatients and outpatients with specific lung conditions and includes careful monitoring of skin reactions due to sensor application. The participation duration and follow-up details are based on the enrollment assessments and data collection periods.

Ultrasound and Respiratory Physiological Signals in Lung Diseases