Actively Recruiting
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases
Led by Masonic Cancer Center, University of Minnesota · Updated on 2026-03-12
200
Participants Needed
1
Research Sites
582 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a treatment guideline for an unrelated umbilical cord blood transplant (UCBT) using a myeloablative preparative regimen for the treatment of hematological diseases, including, but not limited to acute leukemias. The myeloablative preparative regimen will consist of cyclophosphamide (CY), fludarabine (FLU) and fractionated total body irradiation (TBI).
CONDITIONS
Official Title
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with eligible hematological diseases such as acute leukemias, chronic leukemias, lymphomas, myelofibrosis, myelodysplasia, or multiple myeloma
- Specific disease status requirements such as high risk or remission stages depending on disease type
- Patients aged 0 to 55 years
- Availability of suitable unrelated umbilical cord blood unit(s)
- Voluntary written consent given by patient or guardian
You will not qualify if you...
- Previous radiation therapy that prevents safe total body irradiation
- Chemotherapy refractory large cell and high grade non-Hodgkin lymphoma after more than two salvage regimens
- Prior myeloablative transplant within last 6 months if 18 years or younger; prior myeloablative allotransplant or autologous transplant if older than 18
- Extensive prior therapy including more than 12 months of alkylator therapy or more than 6 months with extensive radiation
- Pregnant or breastfeeding
- HIV positive
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Minnesota Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
C
Claudio Brunstein, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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