Testing SEPSys and RESCUE Scores to Predict Sepsis and Patient Deterioration in Hospitalized Adults A Multi-Site Cluster-Randomized Study at University of Maryland Medical System

What this Trial Is About

Researchers are evaluating two new clinical decision support tools designed to predict the risk of sepsis and patient deterioration within four hours in hospitalized adult patients. The study aims to improve healthcare providers awareness of these risks by introducing the SEPSys Score for sepsis prediction and the RESCUE Score for deterioration prediction. This trial is a multi-site, cluster-randomized, factorial stepped-wedge pragmatic clinical trial conducted within the University of Maryland Medical System. The study involves hospitals transitioning through different phases where initially no risk scores are available, then one risk score either SEPSys or RESCUE is visible to clinicians, followed by both scores being available. These scores produce color-coded risk levels from 1 to 4, with higher numbers indicating greater risk. Clinicians use their judgment to recommend treatments and care plans regardless of the availability of the scores. Participants are hospitalized adults in inpatient units of member hospitals who meet specific criteria for score calculation. The study measures the time from an elevated risk score to the recording of vital signs, aiming to assess increased clinical awareness. Other assessments include sepsis diagnosis, treatment timing, deterioration events, and laboratory order frequency. Data collection occurs continually during hospital stays, with an average duration of about five days.

UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial