Concentration of Unbound Cloxacillin in Adults Treated With Continuous Infusion Via Elastomeric Pump

What this Trial Is About

Researchers are studying adults with severe infections caused by the bacterium Staphylococcus aureus to understand how the antibiotic cloxacillin works when given continuously through an elastomeric pump. The study aims to measure the free (unbound) concentration of cloxacillin in the blood to ensure levels are appropriate—not too high or too low. This research will help develop a model to predict the best dosage for individuals based on factors like age, gender, kidney function, and protein levels in the blood. Participants will receive cloxacillin through a continuous infusion using an elastomeric pump. Blood samples will be collected before starting the infusion and then at 4 hours, 24 hours, and 48 hours after beginning the infusion. The study focuses on monitoring the unbound cloxacillin concentration at these time points to gather detailed information on how the drug behaves in the body during continuous treatment. During the study, participants will have blood drawn multiple times to measure cloxacillin levels and monitor their response. Researchers will use these measurements to develop a personalized dosing model. The main outcome tracked is the free cloxacillin concentration over the 48-hour infusion period. The study does not involve blinding or placebo control and is sponsored by Emeli Månsson. Participation lasts at least 48 hours from enrollment to the end of follow-up.

Unbound Cloxacillin Concentrations During Continuous Infusion