Actively Recruiting
Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease
Led by The University of Queensland · Updated on 2024-09-25
28
Participants Needed
1
Research Sites
250 weeks
Total Duration
On this page
Sponsors
T
The University of Queensland
Lead Sponsor
Q
Queensland University of Technology
Collaborating Sponsor
AI-Summary
What this Trial Is About
The present study is a proof-of-concept clinical trial to test the efficacy of low doses of a repurposed anti-epileptic drug (levetiracetam) in treating memory problems in Parkinson's disease (PD). Neuroimaging techniques will be used to determine the effect of the drug on specific brain regions (hippocampal subfields). Finally, baseline brain activity of PD patients with memory problems will be compared to PD patients without memory problems and healthy older adults to determine if activity in specific brain regions (hippocampal subfields) can be used to predict memory problems in PD. This information will be useful for future clinical trials to target drugs to these brain regions.
CONDITIONS
Official Title
Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Parkinson's Disease patients with amnestic Mild Cognitive Impairment
- Parkinson's Disease patients with no memory impairment
- Healthy volunteers
- All participants must be eligible to take MRI scans
You will not qualify if you...
- Dementia
- Contraindication to having MRI
- Bipolar disorder, Schizophrenia, Alcohol or substance abuse
- Major depression
- Suicidal Ideation
- Difficulty complying with protocol requirements
- Significant non-PD neurological disease
- Vascular dementia
- Sensitivity to levetiracetam
- Use of anticonvulsant medications
- Use of other excluded medications
- Severe renal impairment
- Clinically significant abnormalities in B12 or thyroid function test (below normative range for elderly)
- Females of childbearing potential
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Queensland Centre for Clinical Research
Brisbane, Queensland, Australia, 4029
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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