Actively Recruiting
Understanding Brain Mechanisms Involved in Autobiographical Memory
Led by Lucie Bréchet · Updated on 2025-07-15
120
Participants Needed
1
Research Sites
274 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.
CONDITIONS
Official Title
Understanding Brain Mechanisms Involved in Autobiographical Memory
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 35 years old for younger adults without cognitive impairment based on MoCA
- Age 55 years or older for older adults without cognitive impairment based on MoCA
- Willing and able to give informed consent and comply with study requirements
- Age 55 years or older with clinical diagnosis of mild cognitive impairment confirmed by study doctor
- Mini-Mental State Examination (MMSE) score of 18 or higher (21 or higher for mild AD)
- Clinical Dementia Rating (CDR) score of 0.5 or higher
- Demonstrated or reported impairments in autobiographical memory
- Stable dose of memory loss medications (e.g., cholinesterase inhibitors or memantine) for at least 6 weeks
- Minimum education level of 8th grade
You will not qualify if you...
- Montreal Cognitive Assessment (MoCA) score below 26 for cognitively unimpaired participants
- Major psychiatric disorders such as major depressive disorder, schizophrenia, or psychosis
- Blindness or disabilities preventing task performance
- Contraindications for MRI
- Metal in brain, skull, or body not cleared by a doctor (excluding dental fillings)
- Age below 55 years for mild cognitive impairment patients
- History of progressive or genetic neurological disorders other than MCI
- History of acquired neurological diseases such as stroke, traumatic brain injury, or tumors
- History of head trauma with prolonged loss of consciousness
- Poorly controlled headaches or chronic migraine medication
- History of seizures, epilepsy, or relevant family history except benign seizures
- Unstable or uncontrolled medical conditions that may cause emergencies or complications
- Contraindications to transcranial alternating current stimulation including recent seizures, neuroactive drug use, implanted medical devices, or active scalp skin conditions
- Devices such as pacemakers, medication pumps, nerve stimulators unless cleared by a doctor
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Geneva, Campus Biotech
Geneva, Canton of Geneva, Switzerland, 1202
Actively Recruiting
Research Team
L
Lucie Bréchet, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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