Actively Recruiting
Understanding Cycles to Improve Women's Health
Led by University Hospital, Montpellier · Updated on 2025-11-28
320
Participants Needed
1
Research Sites
199 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Montpellier
Lead Sponsor
N
National Research Agency, France
Collaborating Sponsor
AI-Summary
What this Trial Is About
Introduction: The C-HEALTH study investigates how environmental and socio-economic conditions affect women's menstrual cycles and reproductive health. Aim: To compare progesterone levels during the luteal phase among women from different socio-economic backgrounds living in rural and urban areas in southern France. Methods: This is a prospective observational study involving 320 healthy women of reproductive age. * Hormones (progesterone, estradiol) will be measured daily in saliva. * Inflammation (Protéine C Réactive: CRP) will be measured five times per cycle via blood drops. * Participants will wear a smart ring to monitor body temperature and activity. * Daily symptoms and lifestyle data will be collected. * Environmental exposures (pollution, stress, living conditions) will be assessed and linked to menstrual health outcomes.
CONDITIONS
Official Title
Understanding Cycles to Improve Women's Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Woman of childbearing age (18-39 years)
- Not using hormonal contraception for at least 6 months
- Semi-regular menstrual cycles between 21 and 45 days inclusive
- No known history of infertility
- Working in the same environment (urban/rural) as place of residence
- Knowledge of period dates over the last 3 cycles
- Has a freezer at -20°C
You will not qualify if you...
- Diagnosis of PCOS, endometriosis, adenomyosis, diabetes, thyroid disease, hormone-dependent gynecological cancers, coagulation diseases, chronic liver or kidney failure, heart disease, autoimmune disease, autism, psychiatric illness
- Chronic exposure to cocaine, amphetamines, morphine, or ecstasy within 30 days prior
- Chronic exposure to THC within 7 days prior
- Not comfortable with self-sampling (e.g., hematophobia)
- No access to a smartphone
- Unable to wear a connected ring for at least 60 days
- Pregnant or breastfeeding
- Gave birth or breastfed in the 2 months before the study
- Moved less than 2 years ago (except within same environment and less than 20 km)
- Unable to read French
- Failure to give informed consent
- No national health insurance
- Under legal protection, guardianship, or curatorship
- Participating in other human research
AI-Screening
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Trial Site Locations
Total: 1 location
1
Institute of Evolutionary Science of Montpellier
Montpellier, France, 34090
Actively Recruiting
Research Team
A
Alexandra ALVERGNE, PhD
CONTACT
C
Charlotte FAURIE, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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