Studying Brain Activity Differences in Laryngeal Dystonia and Voice Tremor Using Advanced Imaging

What this Trial Is About

Researchers are investigating the neural differences between laryngeal dystonia and voice tremor, two neurological voice disorders that affect speech production. These disorders likely result from specific central nervous system problems rather than physical abnormalities of the larynx. The study aims to identify when and where in the brain these abnormal activities occur during speech, using advanced brain imaging techniques to better understand disorder-specific causes and guide future treatments. The study uses several advanced brain imaging methods including functional MRI, magnetoencephalography MEG, and electroencephalography EEG to observe brain activity during speech and vocal tasks. Participants will undergo procedures such as topical laryngeal sensory block with bupivacaine or a saline placebo to modify sensory feedback during speech. Researchers will also study motor learning and sensorimotor adaptation by altering auditory feedback during speech production to see how the brain responds and adapts. Participants will be evaluated with multiple brain imaging sessions to measure brain signal changes and responses to sensory modulation during speech. The study focuses on functional brain changes related to voice function in both disorders over a period of five years. Researchers will monitor brain activity, motor learning, and sensorimotor feedback effects. The total study duration includes assessments of voice function and neural correlates to understand the underlying brain mechanisms in laryngeal dystonia and voice tremor.

Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor