Actively Recruiting
Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
Led by Massachusetts Eye and Ear Infirmary · Updated on 2025-12-02
165
Participants Needed
1
Research Sites
283 weeks
Total Duration
On this page
Sponsors
M
Massachusetts Eye and Ear Infirmary
Lead Sponsor
U
University of California, San Francisco
Collaborating Sponsor
AI-Summary
What this Trial Is About
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain imaging.
CONDITIONS
Official Title
Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females of diverse racial and ethnic background
- Age 18-80 years
- Native English speakers
- Right-handed
- Normal cognitive status
- Patients with laryngeal dystonia or voice tremor
- Healthy controls without neurological, psychiatric, or otolaryngological problems
You will not qualify if you...
- Unable to give informed consent
- Pregnant or breastfeeding women
- History of neurological problems like stroke, other movement disorders, brain tumors, traumatic brain injury with loss of consciousness, ataxias, myopathies, myasthenia gravis, or demyelinating diseases
- History of psychiatric problems such as schizophrenia, bipolar depression, obsessive-compulsive disorder, alcoholism, or drug dependence
- History of laryngeal problems like vocal fold paralysis, paresis, nodules, polyps, carcinoma, or chronic laryngitis
- Patients with other forms of dystonia
- Patients with dystonia symptoms at rest or mirror dystonia
- Patients not symptomatic due to botulinum toxin treatment or less than 3 months since last injection
- Use of medications affecting the central nervous system
- History of head or neck surgery that changes regional anatomy or innervation
- Presence of certain tattoos or ferromagnetic objects incompatible with MRI (e.g., stimulators, surgical clips, prostheses, artificial heart valves)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts Eye and Ear and University of California San Francisco
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
K
Kristina Simonyan, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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