Actively Recruiting
Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health)
Led by Novo Nordisk A/S · Updated on 2026-05-07
100
Participants Needed
1
Research Sites
113 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical study is to look into how study medicines CagriSema (cagrilintide and semaglutide), cagrilintide, and semaglutide affects muscle health in people with excess body weight and slightly higher than normal blood sugar as they lose weight. Participants will either get CagriSema (a new study drug), cagrilintide (a new study drug), semaglutide (a drug that doctors can already prescribe to treat people with type 2 diabetes and excess body weight) or placebo (a placebo looks like the treatment being tested but doesn't have any active ingredients in it). Which treatment participants will get is decided by chance. Participants will be in this clinical study up to 15 months.
CONDITIONS
Official Title
Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- Age 50 to 70 years at the time of signing consent
- Body mass index (BMI) between 30.0 and 39.9 kg/m2 at screening
- Excess body weight due to excess fat as judged by the investigator
- Desire to lose at least 25% of body weight within 52 weeks of treatment
You will not qualify if you...
- Any leg amputations
- Female participants who are not postmenopausal at screening
- Clinically significant body weight change (≥5%) or dieting attempts within 90 days before screening
- Treatment with any GLP-1 receptor agonist or medication with GLP-1 activity within 90 days before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Aarhus Universitetshospital, Steno Diabetes Center Aarhus
Aarhus N, Denmark, 8200
Actively Recruiting
Research Team
N
Novo Nordisk
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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