Actively Recruiting
Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences
Led by San Diego State University · Updated on 2026-04-13
210
Participants Needed
1
Research Sites
293 weeks
Total Duration
On this page
Sponsors
S
San Diego State University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study is a randomized, placebo-controlled design with the opioid antagonist, oral naltrexone. Following random assignment, participants will take 50mg of naltrexone or placebo once a day for 7 days. On days 1 - 7, participants complete reports of their feelings of social connection and mood in order to assess more naturalistic feelings in response to opportunities for social connection outside of the laboratory setting. Additionally, at the end of each day, they complete a physical symptoms questionnaire. On the 7th day, participants will come to the SDSU MRI scanning facility to complete tasks designed to elicit feelings of social connection in the fMRI scanner. After the scan, feelings in response to the scanner tasks will be collected.
CONDITIONS
Official Title
Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be in good health
- Speak English fluently
- Willing to provide contact information for 4 to 6 close others
- Willing to provide digital photos of 2 close others
- Own a smartphone
You will not qualify if you...
- Have medical devices, implants, or metal objects in or on the body that cannot be removed
- Have tattooed eyeliner
- Have a body shape or size that prevents MRI scanning
- Have claustrophobia
- Have chronic mental or physical illness
- Use prescription medication regularly
- Have difficulty taking pills
- Currently use opioid analgesics
- Have depressive symptoms scoring above 9 on the Patient Health Questionnaire
- Use alcohol excessively
- Test positive on urine drug test
- Have body mass index over 35
- Are pregnant or planning pregnancy within 6 months
- Test positive on urine pregnancy test
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
San Diego State University
San Diego, California, United States, 92120
Actively Recruiting
Research Team
T
Tristen Inagaki, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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