Actively Recruiting
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
Led by University of Ulm · Updated on 2025-07-10
52
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine. Participants will undergo an oral glucose tolerance test combined with a double tracer dilution technique either with atropine infusion or placebo. Healthy individuals and high-risk individuals will be compared to identify possible changes in signaling in high-risk groups. In addition, men and women will be included to take into account possible sex differences.
CONDITIONS
Official Title
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at least 18 years
- Body mass index (BMI) between 20 and 24.9 kg/m2 for healthy groups or more than 28 kg/m2 for overweight groups
- For women, use of hormonal contraception with a single-phase preparation (e.g., Nuvaring)
- Ability to understand and voluntarily sign an informed consent form before study exams
You will not qualify if you...
- Drug or alcohol abuse
- Smoking
- Use of medications affecting blood sugar or central/autonomic nervous system, such as anti-epileptics, beta blockers, dopamine agonists, antidepressants, or antihistamines
- Pre-existing cardiac conditions or known cardiac arrhythmia
- Neurological pre-existing conditions
- Known allergies to study ingredients like paracetamol or atropine
- Known narrow-angle glaucoma
- Known hyperthyroidism
- Known urinary tract or prostate diseases
- Pregnancy or breastfeeding
- At screening, hemoglobin below 12 g/dl for women or below 14 g/dl for men
- No consent to be informed about incidental pathological findings
- Any clinical condition judged by a physician to endanger safety or study success
- Liver dysfunction
- Renal insufficiency
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ulm University Hospital
Ulm, Germany, 89081
Actively Recruiting
Research Team
M
Martin Heni, MD
CONTACT
A
Andrea Geissler
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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