Actively Recruiting
Understanding the Mechanisms of Clonal and Non-clonal Cytopenia Following CAR-T Therapy for Multiple Myeloma or CD19+ Lymphoproliferative Disorder (LPD)
Led by Mayo Clinic · Updated on 2026-01-08
82
Participants Needed
7
Research Sites
159 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial evaluates the impact of preexisting and therapy-emergent germline and somatic variants on cytopenia in patients with multiple myeloma or CD19 positive lymphoproliferative disorder (LPD) following chimeric antigen receptor T-cell (CAR-T) therapy. The most common adverse event after CAR-T therapy is lower than normal blood cells (cytopenia) and up to one third of patients experience cytopenia that last longer than 30 days post-infusion. Germline and somatic variants are changes in genes found using cancer genomic tests. Cancer genetic/genomic testing is a series of tests that find specific changes in cancer cells or in blood deoxyribonucleic acid. Identifying gene mutations may help identify the risk of cytopenia in patients with multiple myeloma or CD19 positive LPD following CAR-T therapy.
CONDITIONS
Official Title
Understanding the Mechanisms of Clonal and Non-clonal Cytopenia Following CAR-T Therapy for Multiple Myeloma or CD19+ Lymphoproliferative Disorder (LPD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 218 years
- Confirmed diagnosis of multiple myeloma based on International Myeloma Working Group criteria or CD19 positive lymphoproliferative disorder based on 2016 WHO classification
- Provide written informed consent
- Willing to provide mandatory bone marrow aspirate specimens during clinical procedures for research
- Willing to provide mandatory hair follicle specimens for research
- Willing to provide saliva and buccal samples for research
- Willing to return to enrolling institution for follow-up during active monitoring phase
You will not qualify if you...
- Not eligible for CAR-T therapy
- Diagnosed with myeloid neoplasm before CAR-T therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Actively Recruiting
2
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
Actively Recruiting
3
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States, 56007
Actively Recruiting
4
Mayo Clinic Health System-Mankato
Mankato, Minnesota, United States, 56001
Actively Recruiting
5
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
6
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin, United States, 54701
Actively Recruiting
7
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, United States, 54601
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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