What is this study trying to find out about stroke?

This study aims to understand motor function and brain reorganization in stroke patients using ultra high-field MRI. Researchers will analyze brain connectivity and motor task performance to develop a brain atlas that may help improve neuroprosthesis use. The project is sponsored by Commissariat A L'energie Atomique and uses advanced imaging and AI techniques.

Who may be eligible for this stroke clinical trial?

Adults aged 18 to 70 years with a confirmed first ischemic stroke occurring more than 6 months ago and persistent upper limb motor deficits may be eligible. Healthy volunteers without neurological or psychiatric history can also participate. Both must be able to undergo MRI and provide informed consent. Please review eligibility criteria for more details.

Is there any cost to participate in this stroke clinical trial?

Study-related care, including the MRI scans and all trial visits, is provided at no cost. However, personal travel and other expenses may vary and are not guaranteed to be covered. Participants should plan accordingly for any out-of-pocket costs.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 70Years

All Genders

Healthy Volunteers

ID07339813

Studying Motor Function and Brain Changes in Stroke Patients Using Advanced High-Field MRI

Led by Commissariat A L'energie Atomique · Updated on 2026-01-14

110

Participants Needed

Research Sites

61 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating motor function and brain reorganization in stroke patients using advanced ultra high-field MRI technology. This study aims to develop a detailed brain atlas by combining structural and functional MRI data from 100 stroke patients to better understand how motor deficits relate to brain connectivity. The research uses machine learning to analyze brain activity and motor task performance, with the goal of improving neuroprosthesis placement for future stroke rehabilitation trials. Participants undergo task-based and resting-state functional MRI sessions that include motor imagery and motor execution tasks. These scans, performed on 3T and 7T MRI machines, collect detailed brain activity and structural data. The study includes both patients with chronic ischemic stroke and healthy volunteers. The data will be analyzed to predict individual motor action intentions and explore patterns of brain reorganization. During the study, participants complete MRI scans along with clinical assessments, including cognitive tests such as the MMSE. Researchers monitor brain function related to motor tasks using fMRI and collect clinical information to feed into artificial intelligence models. The main outcome measure is the accuracy of AI predictions for motor intention. Participants involvement spans from initial MRI data acquisition to detailed analysis, with results expected to support future clinical applications and provide a valuable resource for neuroscience research.

CONDITIONS

Brief Title

Understanding Motor Function in Stroke Patients and Their Functional Brain Reorganization Using Ultra High-field MRI

Who Can Participate

Age: 18Years - 70Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

MRI-confirmed diagnosis of a first ischemic stroke occurring more than 6 months prior to inclusion
Persistent upper-limb motor deficit resulting from the stroke
Absence of significant cognitive impairment with MMSE score 27 or higher
Age between 18 and 70 years
Validation by the inclusion validation committee
Signed informed consent after clear and fair information about the study
For healthy volunteers: age between 18 and 70 years
No history of neurological or psychiatric disease
Signed informed consent after clear and fair information about the study

You will not qualify if you...

Recurrent stroke
Severe aphasia or speech disorders preventing adequate interaction
Severe auditory or visual impairment
Disorders affecting understanding of study motor tasks such as comprehension, attention, or neglect
Associated conditions with estimated life expectancy less than 2 years
History of brain surgery, craniectomy, or cranioplasty
Other causes of motor disability
Alcohol consumption the day before or on the day of examination, or illicit substance use within 48 hours prior to MRI
Absolute contraindications to MRI including pregnancy, metallic foreign bodies, pacemakers, non-compatible neurostimulators, cochlear implants, recent implanted medical devices, metallic heart valves, stents, clips, implantable ports, infusion pumps, non-removable piercings, large tattoos or permanent makeup, transdermal devices with metal, intrauterine devices except Mirena, dental appliances larger than 4 cm, or health conditions incompatible with MRI safety
Not covered by a social security system
Under enhanced protection such as pregnant or breastfeeding women, persons deprived of liberty, legally protected adults, or emergency patients
Women of childbearing potential refusing a pregnancy test
For healthy volunteers: same MRI contraindications, not covered by social security, or under enhanced protection

Research Team

Wissam ZAMOUN, ARC

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Studying Motor Function and Brain Changes in Stroke Patients Using Advanced High-Field MRI

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria