Actively Recruiting
Understanding Motor Function in Stroke Patients and Their Functional Brain Reorganization Using Ultra High-field MRI
Led by Commissariat A L'energie Atomique · Updated on 2026-01-14
110
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The MOTIF-STROKE study is embedded within the BrainSync project, aiming to develop innovative strategies for motor rehabilitation of the upper limb. The primary goal is to construct a high-resolution anatomo-functional disconnection atlas in a cohort of 100 stroke patients, using cutting-edge 3T and 7T MRI. Data acquisition, commencing in Fall 2025, will combine morphological (T1-weighted), functional and diffusion-weighted MRI scans to perform morphometry, functional and structural connectivity analyses with biomarkers of motor deficits. This atlas seeks to correlate connectivity with motor tasks, using dedicated task-related fMRI paradigms and digital consultation tools. The project utilizes machine learning algorithms and functional hyper-alignment to analyze fMRI data, focusing on input features and their impact on prediction accuracy. The ultimate objective is to optimize implantation of WIMAGINE neuroprostheses for the subsequent BCI4STROKE clinical trial. Expected results include identifying clinical subgroups responsive to motor intention decoding, characterizing phenotypes of functional reorganization, and making the 3D brain atlas accessible to the neuroscience community.
CONDITIONS
Official Title
Understanding Motor Function in Stroke Patients and Their Functional Brain Reorganization Using Ultra High-field MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- MRI-confirmed diagnosis of a first ischemic stroke more than 6 months before joining
- Persistent upper-limb motor deficit caused by the stroke
- No significant cognitive impairment (MMSE score 27 or higher)
- Age between 18 and 70 years
- Approval by the inclusion validation committee
- Signed informed consent after receiving clear study information
- Healthy volunteers aged 18 to 70 years
- No history of neurological or psychiatric disease in healthy volunteers
- Signed informed consent for healthy volunteers after receiving clear study information
You will not qualify if you...
- Recurrent stroke
- Severe aphasia or speech disorders preventing study participation
- Severe hearing or vision problems
- Problems with understanding, attention, or neglect affecting motor task comprehension
- Conditions with life expectancy under 2 years
- History of brain surgery, craniectomy, or cranioplasty
- Other causes of motor disability
- Alcohol use the day before or day of examination, or use of illicit psychotropic drugs within 48 hours before MRI
- Absolute MRI contraindications including pregnancy, metallic implants, pacemakers, certain medical devices, large tattoos or permanent makeup, and health issues incompatible with MRI
- Not covered by a social security system
- Under enhanced protection such as pregnant or breastfeeding women, persons deprived of liberty, legally protected adults, or emergency patients
- Women of childbearing potential refusing pregnancy test
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
NeuroSpin, CEA
Gif-sur-Yvette, Île-de-France Region, France, 91191
Actively Recruiting
Research Team
W
Wissam ZAMOUN, ARC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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